Electrochemical Study of Uranyl-Paracetamol Interactions in Solution: Cyclic Voltammetry and Molecular Docking Approaches
Kamal El-din, H., kasim, S., Mohi El-Din, I., Mohsen, T., Gomaa, E., AbouElleef, E. (2025). Electrochemical Study of Uranyl-Paracetamol Interactions in Solution: Cyclic Voltammetry and Molecular Docking Approaches. EKB Journal Management System, (), -. doi: 10.21608/ejchem.2025.388651.11815
Hadwah A. Kamal El-din; safa kasim; Ibrahim E. Mohi El-Din; Tarek A. Mohsen; Essam A. Gomaa; Elsayed M AbouElleef. "Electrochemical Study of Uranyl-Paracetamol Interactions in Solution: Cyclic Voltammetry and Molecular Docking Approaches". EKB Journal Management System, , , 2025, -. doi: 10.21608/ejchem.2025.388651.11815
Kamal El-din, H., kasim, S., Mohi El-Din, I., Mohsen, T., Gomaa, E., AbouElleef, E. (2025). 'Electrochemical Study of Uranyl-Paracetamol Interactions in Solution: Cyclic Voltammetry and Molecular Docking Approaches', EKB Journal Management System, (), pp. -. doi: 10.21608/ejchem.2025.388651.11815
Kamal El-din, H., kasim, S., Mohi El-Din, I., Mohsen, T., Gomaa, E., AbouElleef, E. Electrochemical Study of Uranyl-Paracetamol Interactions in Solution: Cyclic Voltammetry and Molecular Docking Approaches. EKB Journal Management System, 2025; (): -. doi: 10.21608/ejchem.2025.388651.11815

Electrochemical Study of Uranyl-Paracetamol Interactions in Solution: Cyclic Voltammetry and Molecular Docking Approaches

Egyptian Journal of Chemistry
Articles in Press, Accepted Manuscript, Available Online from 04 August 2025  XML
Document Type: Original Article
DOI: 10.21608/ejchem.2025.388651.11815
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Authors
Hadwah A. Kamal El-din1; safa kasim2; Ibrahim E. Mohi El-Din3; Tarek A. Mohsen4; Essam A. Gomaaorcid 5; Elsayed M AbouElleef email orcid 6
11 Chemistry Department, Faculty of Science, Port Said University, Port Said, Egypt. 2 Department of Medical Analysis, Ophthalmology Center, Mansoura University, Mansoura, Egypt.
2chemistry department Mansoura university
3Chemistry Department, Faculty of Science, Port Said University, Port Said, Egypt.
4Ophthalmology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
5Chemistry Department, Faculty of Science, El-Mansoura University Egypt
6Basic Sciences Department, Delta Higher Institute for Engineering and Technology, 35681-Dakhlia, Mansoura, Egypt.
Abstract
The electrochemical behaviour of paracetamol was investigated in various electrolyte environments, with a focus on its interaction with uranyl ions in alkaline medium. Cyclic voltammetry revealed evidence of complex formation, supported by shifts in peak potentials and increased current responses. Thermodynamic parameters were estimated from electrochemical data, confirming the stability and spontaneity of the complexes. Molecular docking studies with viral (7JWY) and cancer-related (5IXB) proteins were also performed to evaluate theoretical binding affinity. The findings suggest that paracetamol can form stable coordination complexes with uranyl ions and potentially interact with biologically relevant targets.
Keywords
Uranyl nitrate; Solvation parameters; stability constants; Paracetamol; Cyclic voltammetry
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