Evaluation of Serum Pentraxin 3 and High Sensitive CRP in Female Patients with Gestational Diabetes Mellitus in Second Trimester of Pregnancy

Refae, Alyaa A.S.; Abd El-Azeem, Hanan G.; Seddik, Mohamed I.; Abbas, Ahmed M.; Hosny, Mai M.

doi:10.21608/ejmm.2025.406487.1794

	Evaluation of Serum Pentraxin 3 and High Sensitive CRP in Female Patients with Gestational Diabetes Mellitus in Second Trimester of Pregnancy
Egyptian Journal of Medical Microbiology
Volume 34, Issue 4, October 2025
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2025.406487.1794
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Authors
Alyaa A.S. Refae¹; Hanan G. Abd El-Azeem¹; Mohamed I. Seddik¹; Ahmed M. Abbas²; Mai M. Hosny ¹
¹Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
²Department of Obstetrics and Gynecological, Faculty of Medicine, Assiut University, Assiut, Egypt
Abstract
Background: Gestational Diabetes Mellitus (GDM) is a condition characterized by abnormal glucose metabolism during pregnancy, leading to adverse outcomes for both mother and child. Early intervention can reduce GDM incidence, excessive gestational weight gain, and complications like hypertensive disorders, cesarean delivery, and fetal macrosomia. Both Pentraxin-3(PTX3) and high sensitive C-reactive protein (hs-CRP) may play a role in GDM development, with elevated levels in the second trimester suggesting their potential as biomarkers for early GDM prediction, prevention, and long-term cardiovascular risk assessment. Objective: This study aimed to assess the value of serum Pentraxin-3 and high sensitive CRP in females with gestational diabetes mellitus in second trimester of pregnancy in comparable to females with normal pregnancy and to study correlations between serum Pentraxin-3 and High sensitive CRP in gestational diabetes. Methodology: The study included two groups: 45 pregnant female patients with gestational diabetes in second trimester of pregnancy and 45 pregnant females in second trimester of pregnancy not diagnosed with gestational diabetes. The serum level of PTX-3 was measured by ELISA. The serum level of hs-CRP was assessed by a Dimension Exl 200 system analyzer. Results: PTX3 is significantly elevated in the "Case" group (p<0.001). This indicates a pronounced inflammatory state associated with the condition of the "Case" group. Hs-CRP is significantly elevated in the "Case" group(p=0.005). This indicates a pronounced inflammatory state associated with the condition of the "Case" group. Conclusion: There is significant association between elevated levels of PTX3, hs-CRP in GDM.
Keywords
Gestational diabetes mellitus; pentraxin 3; high sensitive-CRP and ELISA


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