Association between Transforming Growth Factor β1 Gene Polymorphism and Chronic Spontaneous Urticaria | ||
| Zagazig University Medical Journal | ||
| Volume 31, Issue 9, September 2025, Pages 4747-4759 PDF (1.08 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2025.399690.4032 | ||
| Authors | ||
| Amal Hassan Atta1; Esraa Ahmed Mahmoud Ahmed* 2; Manal Mohamed Fawzy3; Eman Salah Elgharabawy4 | ||
| 1Professor of Medical Microbiology and Immunology, Faculty of Medicine - Zagazig University | ||
| 2Demonstrator of Medical Microbiology and Immunology, Faculty of Medicine - Zagazig University | ||
| 3Assistant Professor of Dermatology, Venereology and Andrology, Faculty of Medicine - Zagazig University | ||
| 4Assistant Professor of Medical Microbiology and Immunology, Faculty of Medicine - Zagazig University | ||
| Abstract | ||
| Background: Chronic spontaneous urticaria (CSU) is a prevalent skin disease with an unclear pathogenesis. Transforming growth factor beta 1 (TGF-β1) is an immunoregulatory cytokine potentially incorporated in autoimmune as well as inflammatory diseases. Methods: This case-control study was carried out involving 24 CSU patients and 24 age- and sex-matched healthy controls. All subjects were genotyped for detection of TGF-β1 codon 10 (rs1982073) and codon 25 (rs1800471) polymorphisms using Amplification Refractory Mutation System PCR (ARMS-PCR). Results: The incidence of the G/C genotype at codon 25 was significantly higher amongst CSU patients than controls (87.5% vs. 37.5%, p = 0.005), having an odds ratio (OR) of 10.9 (95% CI: 2.5–47.1). The C allele was also more common among patients (p = 0.031; OR =2.62 (95% CI: 1.08–6.32). The risk of CSU is 10.9 times higher among those who are CG genotype. C allele significantly increases the risk of CSU by 2.62 folds. Non-significant correlations was found in distribution of genotypes for TGF-β1 codon 10 between patients and controls (p = 0.53), also between TGF-β1 gene polymorphisms (at codon 10 and codon 25) and age (p = 0.5, >0.999), gender (p >0.999), ASST reactivity (p =0.4, 0.2), angioedema (p = 0.5, >0.999), or UAS7 scores (p = 0.1). Conclusion: TGF-β1 gene polymorphism at codon 25 is associated with a higher risk of CSU, with carriers of the G/C genotype showing almost 10.5-fold increased risk. However, these polymorphisms did not affect clinical severity or other features. | ||
| Keywords | ||
| Transforming Growth Factor β; Gene Polymorphism; Chronic Spontaneous Urticaria | ||
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