Assessment of Serum Glial Cell Line-Derived Neurotrophic Factor as a diagnostic marker in patients with liver cirrhosis | ||||
| Scientific Journal for Damietta Faculty of Science | ||||
| Volume 15, Issue 2, August 2025, Page 120-128 PDF (1.06 MB) | ||||
| Document Type: Original articles | ||||
| DOI: 10.21608/sjdfs.2025.391328.1235 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ihssin Abdulla Abubaker Faraj  1; Mohamed Mohamed Abdel-aziz2; Lamiaa Deef3; lotfy zakaria habbak4; Amina M. R. El-Sayed5
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| 1Zoology, Faculty of science, Damietta university, Damietta, Egypt. | ||||
| 2Gastrointestinal Surgery Center, faculty of Medicine, Mansoura University | ||||
| 3Professor of Molecular Biology, Department of Zoology, Faculty of Science, Damietta University | ||||
| 4Professor of Immunology &Experimental Zoology. Zoology department, faculty of science, Damietta University, Damietta, Egypt | ||||
| 5Gastrointestinal Surgery Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt. | ||||
| Abstract | ||||
| Background: Cirrhosis is often irreversible and progressive phase of chronic liver disease recognized by loss of liver function and fibrotic remodeling. The aim of this study is to evaluate the diagnostic utility of glial cell line-derived neurotrophic factor (GDNF) in distinguishing cirrhosis patients from healthy individuals. Methods: A total of 61 participants were enrolled, consisting of 42 cirrhotic patients and 19 healthy controls. Serum GDNF, standard liver enzymes, kidney function parameters, and complete blood count indices were assessed. Results: Significant alterations were observed in liver profile markers such as decreased albumin and elevated bilirubin, aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), and international normalized ration (INR) in cirrhotic patients (P<0.001). Hematological analysis revealed anemia, thrombocytopenia, and elevated red cell distribution width (RDW), along with increased neutrophil-to-lymphocyte ratio (NLR), indicative of systemic inflammation. GDNF levels were significantly elevated in cirrhosis cases, with a median of 2.3 ng/mL compared to 1.75 ng/mL in controls (P=0.001). GDNF demonstrated moderate diagnostic ability with an area under the ROC curve (AUC) of 0.699, sensitivity of 69%, and specificity of 73.7%, suggesting its potential as a non-invasive biomarker. RDW and NLR exhibited the highest diagnostic performance, with AUCs of 0.863 and 0.829, respectively. Conclusion: This result supports the integration of GDNF and other novel biomarkers to improve the early detection and clinical assessment of liver cirrhosis. | ||||
| Keywords | ||||
| Cirrhosis; Glial cell line derived neurotrophic factor (GDNF); Liver Enzymes | ||||
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