Prevalence Trends and Diagnostic Biomarkers in Chronic Liver Diseases

Faraj, Ihssin Abdulla Abubaker; Abdel-aziz, Mohamed Mohamed; Deef, Lamiaa; Habbak, Lotfy zakaria; El-Sayed, Amina M. R.

doi:10.21608/sjdfs.2025.393515.1237

	Prevalence Trends and Diagnostic Biomarkers in Chronic Liver Diseases
Scientific Journal for Damietta Faculty of Science
Volume 15, Issue 2, August 2025, Page 129-139 PDF (947.78 K)
Document Type: Review article.
DOI: 10.21608/sjdfs.2025.393515.1237
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Authors
Ihssin Abdulla Abubaker Faraj ¹; Mohamed Mohamed Abdel-aziz²; Lamiaa Deef³; Lotfy zakaria Habbak⁴; Amina M. R. El-Sayed⁵
¹Zoology, Faculty of science, Damietta university, Damietta, Egypt.
²Gastrointestinal Surgery Center, faculty of Medicine, Mansoura University
³Professor of Molecular Biology, Department of Zoology, Faculty of Science, Damietta University
⁴Zoology department, faculty of science, Damietta University, Damietta, Egypt
⁵Gastrointestinal Surgery Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Abstract
Chronic liver disease (CLD) significantly contributes to global morbidity and mortality, covering a spectrum of disorders with diverse etiologies. Hepatocellular damage in cirrhosis leads to hypoalbuminemia, increased bilirubin and extended prothrombin time. In spite of the advancement in treatment modalities, CLD still presents many complications. Accurate diagnosis, prognosis, and monitoring of chronic liver disease depend profoundly on the assessment of several biomarkers. This review provides a focused overview of key biochemical and hematological biomarkers utilized in the evaluation of major chronic liver disease types, covering viral hepatitis, non-alcoholic fatty liver disease (NAFLD). For each disease category, we discuss the clinical utility of traditional liver function tests (ALT, AST, bilirubin, albumin), markers of fibrosis (platelet count, APRI score, FIB-4 index), and other relevant hematological parameters. By synthesizing current evidence on the diagnostic and prognostic value of these biochemical and hematological indicators across different CLD etiologies, this review aims to provide a practical resource for clinicians and researchers in the field of hepatology.
Keywords
Chronic liver diseases (CLD); Biomarkers; Hepatitis B virus (HBV); Hepatitis C virus (HCV)


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