Effect of Dapagliflozin on N-Terminal Prohormone of Brain Natriuretic Peptide and some Biochemical Parameters in Patients with Heart Failure | ||
| Journal of Bioscience and Applied Research | ||
| Article 20, Volume 11, Issue 3, September 2025, Pages 953-961 PDF (783.94 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbaar.2025.374702.1184 | ||
| Authors | ||
| Saleh Netish Khashlok; Alyaa Majid* | ||
| Department of Chemistry, College of Science, University of Thi-Qar, Thi-Qar, 64001, Iraq. | ||
| Abstract | ||
| The cardiovascular system benefits from dapagliflozin, a member of the class of hypoglycemia medications known as SGLT-2 inhibitors. The purpose of the current research is to compare the levels of NT-Pro BNP, creatinine, urea, K, and Na in patients to those in healthy individuals (controls). There were 150 participants in the research: 100 patients with Type 2 Diabetes Mellitus (T2DM) and heart failure (HF), and 50 controls. Based on age, the patients are split into two groups (40-70). Whereas the second group (B) just received Lasix, the first group (A) received both Lasix and dapagliflozin. Compared with the control group, group B's serum concentration of NT-Pro BNP, creatinine, and urea increased significantly (p ≤ 0.050). Compared to controls, group B had a significant drop in serum Na concentration (p ≤ 0.05). Serum concentrations of NT-Pro BNP, Creatinine, Urea, and Na in group B are not significantly different from those in group A at the time of admission. When compared to group A, group B exhibits significant differences in serum K concentration. Serum concentrations of NT-ProBNP, Creatinine, Urea, Potassium, and Sodium do not differ significantly between groups B and A at 7 days, according to the data. Additionally, in comparison with the day of baseline, the concentration of serum NT-pro-BNP in patients in groups B and A was significantly lower on the seventh day of baseline. Dapagliflozin works well to lower NT-Pro BNP levels and alleviate the symptoms of HF. It improves cardiac function, quality of life, and reduces fluid retention. | ||
| Keywords | ||
| Lasix; Dapagliflozin; Kidney Function Tests; NT-Pro BNP; Heart Failure | ||
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