Synthesis, characterization and antibacterial study of the synthesized flavone derivatives | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 05 August 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2025.407397.3049 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Farah Dheyaa Ahmed Haddad 
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| General Directorate of Education Baghdad Karkh first, Baghdad, Iraq | ||||
| Abstract | ||||
| Aim: To synthesize a series of the flavone derivatives and estimate their antibacterial efficacy against both Gram-positive and Gram-negative bacteria. Methods: The Claisen-Schmidt condensation of 2-hydroxyacetophenone and benzaldehyde or para-substituted benzaldehydes with SOCl2/ETOH was used as a catalyst. In contrast, oxidative cyclization of the obtained 2'-hydroxychalcone derivatives in dimethylsulfoxide (DMSO) with iodine affords the corresponding flavone derivatives. FTIR spectroscopy and other physicochemical properties were utilized to confirm and characterize the structure of the synthesized chalcone and flavone derivatives. The antibacterial evaluation employs the filter paper disc plate method. Results: Excellent yields of chalcone intermediates and their final corresponding flavone derivatives. The structures of these intermediates and their final products were confirmed by FTIR spectroscopy and other physicochemical properties. The antibacterial evaluation of these synthesized flavones revealed a promising activity against pathogenic bacteria, providing hope for the further development of antibacterial agents for commercial use. Conclusion: The new synthesized series of flavone derivatives holds the potential as candidates for further investigation in the field of antibacterial therapies. | ||||
| Keywords | ||||
| Chalcones; Flavones; Chalcone and flavones synthesis; Antibacterial activity | ||||
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