Correlation of some Cytokines Concentration of Gastric Ulcer Patients with H. pylori infection in Al Najaf Provenience | ||||
| Egyptian Journal of Medical Microbiology | ||||
| Volume 35, Issue 2, April 2026 | ||||
| Document Type: New and original researches in the field of Microbiology. | ||||
| DOI: 10.21608/ejmm.2025.407288.1799 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ali S. Ard  1; Mahdi H, Alammar2
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| 1Najaf Health Office | ||||
| 2Department of Biology, College of Science, University of Kufa, Najaf, Iraq | ||||
| Abstract | ||||
| Background: Helicobacter pylori, or H. pylori, a Gram-negative spiral-shaped bacterium affects more than half of the people in the world. The adaptable immune reaction comes after the first line of defense epithelial cells and the cell of innate immunity that make up. This study aims to find out if IL-8, IL6, Nuclear Factors Kappa B (NFKB), and IL-17 can be used as biomarkers in people who have H. pylori infection according to specialist physician consult. Methodology: The 80 samples of this study were collected from patients that had H. pylori infection according to specialist physician of Gastric Tract diagnosis, then split to two groups: 40 were patients and 40 were from a control group for both sexes and age during the period from February to September 2024 at digestive system Center, Al-Sadr Medical Hospital/Najaf Provenance. Five ml of Blood samples were taken from all of the subjects to make a determination H. pylori antibodies test. Also, stool specimens were collected for H. pylori Ag diagnosis. Serum was used for detect IL-8, IL6, NFKB and IL-17 concentration by ELISA technique. Results: The current study found that the levels of NFKB, IL-8, IL-6, and IL-17A pg/ml were higher in H. pylori patients compared to healthy controls (42.58 ± 6.58), (21.87 ± 6.75) pg/ml with (p >0.05), (57.26 ± 17.7 ), (27.87 ± 11.29) pg/ml (p >0.05), (7.59 ± 2.06),(2.16 ± 0.66)pg/ml (p >0.05), and 49.35 ± 12.64) pg/ml (P <0.05), respectively. In people who had H. pylori, when IL-17 and IL-8 were together, they had a strong good interaction. Conclusion: The pro-inflammatory cytokines played a role in changing immune reactions in patients with the H. pylori infection. | ||||
| Keywords | ||||
| H. pylori; IL-8; IL-6; IL-17; NFKB | ||||
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