Role Genetic risk factors of FGFR4 Gene Polymorphism Association with Cholecystitis Infection | ||
| Journal of Bioscience and Applied Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 06 August 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbaar.2025.396579.1232 | ||
| Authors | ||
| Mayameen Hussein Ghitheeth* ; Najlaa Abdullh D | ||
| Department medical biotechnology ,College of Biotechnology ,University of Al-Qadisiyah ,Iraq | ||
| Abstract | ||
| Background: The human FGFR4 gene, which codes for it, is located within a roughly 11 kb section on chromosome 5's long arm (5q35.1), Three of the five distinct transcripts encoded by this gene produce FGFR4 isoform 1, which contains 802 amino acids and weighs between 95 and 110 kDa depending on glycosylation.. Objectives: the aims of our current reaserch Analyze the role of the mutation and define the realationship between in the FGFR4 gene(rs351855) using ARMS –PCR technique Methodology: In this study, 100 samples were collected, 50 samples from people with cholecystitis and 50 samples from healthy people during the period from October 2024 to January 2025 in two health facilities in Diwaniyah General Teaching Hospital and the Public Health Laboratory after which ARMS-PCR was used An important College of Medical Biotechnology, Al-Qadisiyah University, Iraq. Facilitation document with document number 1880 date 17/9/2024. - Results: the chi-square test for The genotype frequency distribution showed that the differences between the sick and control groups were statistically significant (Table 1). Heterozygous G/A was found to be a significant risk demonstrator with OR = 3.04 and the homozygous AA genotype to be a significant risk factor with OR = 2.78. That is, the disease occurred in AA homozygous people almost three times more often than people with other genotypes. . Conclusions The present study demonstrated a significant association between fgfr4(rs351855)polymorphism and susceptibility | ||
| Keywords | ||
| ARMS –PCR; FGFR4; cholecystis | ||
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