The Effect of Ashwagandha Roots on Diabetic of Male Rats | ||
| Egyptian Journal of Nutrition | ||
| Volume 40, Issue 2, June 2025, Pages 68-78 PDF (909.02 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/enj.2025.446142 | ||
| Authors | ||
| 1Nourelhouda M Moustafa1; 2Maha S Ziada2; 3Mohammed H Haggag3 | ||
| 11Nutrition and Food Science Department, Faculty of Home Economics, Helwan University, Cairo, Egypt | ||
| 22 Animal Reproduction Research Institute Agricultural Research Center, Giza, Egypt | ||
| 33Therapeutic Nutrition Department, Faculty of Nutrition Science. Helwan University, Cairo, Egypt | ||
| Abstract | ||
| ABSTRACT The present work aimed to investigate the effect of ashwagandha root powder (ARP) administrative by diabetic male rats. Thirty male rats were randomly divided into 5 equal groups (n=6). The 1st group was fed the basal diet for 56 days as a negative control (-ve). The 2nd group injected with a single dose of Alloxan to induce diabetes. Groups 3-5 as the same of group two but fed on basal diet containing 4, 6 and 8% of ARP, respectively. Results of chemical composition of ARP showed that each 100 g contained fat, fiber, protein, carbohydrate, ash and moisture at 0.9, 33.3, 3.3, 51.1, 4.2 and 7.2%, respectively. Polyphenolic compounds, Quercetin recorded 22.776 mg/100g, followed by Vanillic acid 18.66 mg/100g. The antioxidant activity DPPH was 63.69 % in the high tested level 7% of sample. Biological study showed that, administration of ARP to diabetic rats decreased weight gain, blood glucose level, TC, TG, LDL and MDA. On the other hand, levels of serum Insulin, HDL-c and CAT, were increased by ARP administration. In conclusion, dietary supplementation with ashwagandha root powder (ARP) resulted in a significant improvement in biomarkers associated with diabetes and hypercholesterolemia. These findings suggest that the intake of ARP may offer potential benefits for individuals with diabetes. | ||
| Keywords | ||
| Key words: ashwagandha roots; antioxidant; diabetic Rat; hypercholesterolemia | ||
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