The Effect of Ashwagandha Roots on Diabetic of Male Rats
Moustafa, 1., Ziada, 2., Haggag, 3. (2025). The Effect of Ashwagandha Roots on Diabetic of Male Rats. EKB Journal Management System, 40(2), 68-78. doi: 10.21608/enj.2025.446142
1Nourelhouda M Moustafa; 2Maha S Ziada; 3Mohammed H Haggag. "The Effect of Ashwagandha Roots on Diabetic of Male Rats". EKB Journal Management System, 40, 2, 2025, 68-78. doi: 10.21608/enj.2025.446142
Moustafa, 1., Ziada, 2., Haggag, 3. (2025). 'The Effect of Ashwagandha Roots on Diabetic of Male Rats', EKB Journal Management System, 40(2), pp. 68-78. doi: 10.21608/enj.2025.446142
Moustafa, 1., Ziada, 2., Haggag, 3. The Effect of Ashwagandha Roots on Diabetic of Male Rats. EKB Journal Management System, 2025; 40(2): 68-78. doi: 10.21608/enj.2025.446142

The Effect of Ashwagandha Roots on Diabetic of Male Rats

Egyptian Journal of Nutrition
Volume 40, Issue 2, June 2025, Page 68-78  XML PDF (909.02 K)
Document Type: Original Article
DOI: 10.21608/enj.2025.446142
View on SCiNiTO View on SCiNiTO
Authors
1Nourelhouda M Moustafa1; 2Maha S Ziada2; 3Mohammed H Haggag3
11Nutrition and Food Science Department, Faculty of Home Economics, Helwan University, Cairo, Egypt
22 Animal Reproduction Research Institute Agricultural Research Center, Giza, Egypt
33Therapeutic Nutrition Department, Faculty of Nutrition Science. Helwan University, Cairo, Egypt
Abstract
ABSTRACT
     The present work aimed to investigate the effect of ashwagandha root powder (ARP) administrative by diabetic male rats. Thirty male rats were randomly divided into 5 equal groups (n=6). The 1st group was fed the basal diet for 56 days as a negative control (-ve). The 2nd group injected with a single dose of Alloxan to induce diabetes. Groups 3-5 as the same of group two but fed on basal diet containing 4, 6 and 8% of ARP, respectively. Results of chemical composition of ARP showed that each 100 g contained fat, fiber, protein, carbohydrate, ash and moisture at 0.9, 33.3, 3.3, 51.1, 4.2 and 7.2%, respectively. Polyphenolic compounds, Quercetin recorded 22.776 mg/100g, followed by Vanillic acid 18.66 mg/100g. The antioxidant activity DPPH was 63.69 % in the high tested level 7% of sample. Biological study showed that, administration of ARP to diabetic rats decreased weight gain, blood glucose level, TC, TG, LDL and MDA. On the other hand, levels of serum Insulin, HDL-c and CAT, were increased by ARP administration. In conclusion, dietary supplementation with ashwagandha root powder (ARP) resulted in a significant improvement in biomarkers associated with diabetes and hypercholesterolemia. These findings suggest that the intake of ARP may offer potential benefits for individuals with diabetes.
Keywords
Key words: ashwagandha roots; antioxidant; diabetic Rat; hypercholesterolemia
Statistics
Article View: 38
PDF Download: 36