Effect of Bitter Melon (Momordica charantia) Juice on Blood Glucose Level and Lipid Profile in Diabetic and Prediabetic Rats | ||||
| مجلة الاقتصاد المنزلي | ||||
| Volume 41, Issue 3, September 2025, Page 1-22 PDF (509.46 K) | ||||
| Document Type: المقالة الأصلية | ||||
| DOI: 10.21608/jhe.2025.446283 | ||||
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| Authors | ||||
| Rahmah Saeed Hasan; Nafisa Hasan El-Banna; Hany Gaber EL-Masry | ||||
| Nutrition and Food Science Department, Faculty of Home Economics, Helwan University | ||||
| Abstract | ||||
| This study aimed to evaluate the effect of bitter melon juice (BMJ) on blood glucose level and lipid profile of diabetic and prediabetic rats. Forty-two rats were separated into three group. 1st group, rats (n=6) was fed on basal diet and kept as negative control group, 2st group: (Diabetic): rats (n=18), were injected with a single dose of subcutaneous injection of alloxan (120 mg/kg) to induce diabetes. After diabetes induction rats were divided as follow: subgroup 1 served as the control positive group and 2 treated rat subgroups were fed on basal diet and orally administrated with 1and 2 ml/day of BMJ, respectively. 3st group: (Prediabetic): rats (n=18), High fat diet (HFD) group as induction of prediabetic rats. After prediabetic induction rats were divided as follow: subgroup 1 served as the control positive group and 2 treated rat subgroups were fed on HFD and orally administrated with 1and2ml/day of BMJ, respectively. Results revealed that diabetic and pre diabetic rats treated with oral administration of 1 and 2 ml/day of BMJ caused a significant decrease in blood glucose, increase of insulin. Furthermore, diabetic and pre diabetic rats treated with oral administration of BMJ had improved of body weight accompanied by a significant decrease in levels of lipid profile as well as in liver functions (ALT, AST and ALP), kidney function (Urea, Creatinine and Uric Acid), while were recorded a significant increase in a high-density lipoprotein-cholesterol (HDL-C). In addition, significantly reduced Malondialdehyde (MDA) while GPX were significantly (P<0.05) increased. Conclusion, bitter melon juice could introduce a potential natural therapy against diabetic and prediabetic. | ||||
| Keywords | ||||
| Momordica charantia; Bitter Melon; hypoglycemic; Diabetes mellitus; prediabetic; Rats | ||||
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