Investigating Nitrogen Containing Compounds as Promising Anticancer Agents | ||||
| Records of Pharmaceutical and Biomedical Sciences | ||||
| Volume 9, Issue 1, March 2025, Page 113-122 PDF (653.15 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/rpbs.2025.402080.1386 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Noura Zakaria Elzoghbi  1; Safaa Kishk 2; khaled Mohamed Darwish3; Ismail Salama4
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| 1Department of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt. | ||||
| 2Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt | ||||
| 3a. Department of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University b. Department of Medicinal Chemistry, Faculty of Pharmacy, Galala University, New Galala 43713, Egypt. | ||||
| 4Department of Medicinal Chemistry, Faculty of Pharmacy - Suez Canal University | ||||
| Abstract | ||||
| Cancer is known as a large group of diseases with one shared thing that normal cells become cancerous cells which speedily multiply then spread. Colorectal cancer is the one of top two most common cause of death worldwide. Most Chemotherapy drugs can badly damage vital human organs so medicines are prescribed with the chemotherapy for the protection of body normal cells. New targets for cancer treatment have been over years to help discover new drugs with higher potency and lower side effects. New thiazole based compounds can be developed by reacting various chemical scaffolds are considered promising anti-cancer agents. They are reported with the inhibitory effect on different kinases including epidermal growth factor receptor (EGFR) that play a main role in cancerous cell growth, proliferation and metastasis through the transmission of cellular signaling. Molecular docking analyses were performed to assess the binding affinities and interaction patterns of the compounds within the active site of EGFR. Furter, in silico toxicity and target interaction predictions were carried out for the five compounds using the ProTox 3.0 platform. | ||||
| Keywords | ||||
| Colorectal cancer; EGFR; in silico toxicity; Thiazole | ||||
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