Impact of Obstructive Sleep Apnea and Obesity on Hypoxia Inducible Factor 1-alpha Protein Level | ||
| SVU-International Journal of Medical Sciences | ||
| Volume 8, Issue 2, July 2025, Pages 349-359 PDF (363.44 K) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/svuijm.2025.366020.2138 | ||
| Authors | ||
| Rehab H. Abdel-Aziz1; Eptehal Dongol2; Omyma Galal Ahmed3; Mohammed Hassan4; Fatma Rabea A. Hamdan* 1; Rana Toghan1 | ||
| 1Physiology Department, Faculty of Medicine, South Valley University, Qena, Egypt. | ||
| 2Chest Department, Faculty of Medicine, South Valley University, Qena, Egypt. | ||
| 3Physiology Department, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||
| 4Department of Medical Biochemistry, Faculty of Medicine, South Valley University, Qena, Egypt. | ||
| Abstract | ||
| Background: Obstructive sleep apnea (OSA) and obesity lead to a hypoxic state, increasing the hypoxia-inducible factor 1-alpha (HIF1-α) level to achieve cellular adaptation. Objectives: To clarify the correlation between HIF 1-α level with both OSA severity and obesity. Patients and methods: A case-control study was conducted on patients attending the sleep disorders unit at South Valley University Hospital from March 2022 to July 2023. 64 patients were diagnosed by a standard nocturnal polysomnography (PSG). A blood sample was taken to detect HIF 1-α level. Results: Considering the HIF 1-α level, our study disclosed no significant difference between controls and OSA patients (P = 0.92), while there was a statistically considerable difference between different OSA groups (P = 0.001). Also, there are statistically significant positive correlations between HIF 1-α serum level with all of the following, AHI (r = 0.381, P = 0.008), the number of desaturation index (ODI) (r = 0.51, P < 0.001). and waist circumference (WC) (r = 0.291, P = 0.045). Conclusion: OSA severity is associated with an increase in HIF-1α levels and neck and waist circumference reinforces the role of obesity and fat distribution in OSA pathophysiology. | ||
| Keywords | ||
| Hypoxia-inducible factor 1- alfa (HIF1-α); Obstructive sleep apnea (OSA); Obesity | ||
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