Relationship between Monocyte to High-Density Lipoprotein Ratio and Contrast-Induced Nephropathy in Patients with Acute Coronary Syndrome Treated by Primary Percutaneous Coronary Intervention | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2025, Issue 2, February 2025, Page 70-66 PDF (297.41 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/aimj.2025.446416 | ||||
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| Authors | ||||
| Moustafa Ibraheem Mokarrab1; Abdelaal Alsayed Abdelrahman Alkhouly2; Ahmed Shawky Ahmed Ali Algammal1 | ||||
| 1Cardiology Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| 2Cardiology, Islamic Center of Cardiology, Al-Azhar University, Cairo | ||||
| Abstract | ||||
| Background: In patients with acute coronary syndromes (ACS), contrast-induced nephropathy (CIN) is a common consequence of using contrast during percutaneous coronary procedures. It is significantly linked to high rates of death and morbidity. Protective measures and better clinical outcomes can only be achieved if individuals with ACS who are at high risk of CIN are identified and treated early. Aim and objectives: To examine the relationship between CIN and the ratio of monocytes to high-density lipoprotein (HDL) in patients who have undergone primary percutaneous coronary intervention (PCI) for ACS. Patients and methods: One hundred fifty patients hospitalized at Damanhur Medical National Institute with acute coronary syndrome between October 2023 and July 2024 and who were treated with primary PCI were included in this retrospective study. Results: Twenty individuals (13.33%) experienced CIN. Compared to the non-CIN group, the CIN (+) group had a substantially higher monocyte to high-density lipoprotein cholesterol ratio (MHR) (0.023±0.01) 108/mg. With a p-value of less than 0.001, a strong positive connection was found between MHR and creatinine levels after 24, 48, and 72 hours. To predict contrast-induced nephropathy with an 80% sensitivity and 76.6% specificity, ROC statistical analysis demonstrated that MHR>0.0171 was the optimal cutoff value. Conclusion: It is possible to predict the development of CIN in patients with ACS who are undergoing primary PCI by measuring preprocedural MHR, which is a simple inflammatory marker that is readily available upon admission at most centers. This will allow us to take adequate precautions and improve clinical outcomes. | ||||
| Keywords | ||||
| Monocyte; HDL; CIN; ACS; Primary PCI | ||||
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