Measurement of regional liver function with dynamic gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging | ||||
| International Journal of Medical Arts | ||||
| Articles in Press, Accepted Manuscript, Available Online from 09 August 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2025.373335.2168 | ||||
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| Authors | ||||
Aboelyazid Elkilany  1; Mohamed Saied Abdelgawad2; Mohamed Al-Warraky1; Timm Denecke3; Enas Mohamed Korayem1
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| 1Department of Diagnostic and Interventional Medical Imaging, National Liver Institute, Menoufia University, Egypt | ||||
| 2Department of Diagnostic and Interventional Medical Imaging, National Liver Institute, Menoufia University | ||||
| 3Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany | ||||
| Abstract | ||||
| Background: Assessing regional liver function is crucial in patients scheduled for liver resection to support risk assessment and anticipate post-hepatectomy liver failure (PHLF). Aim of the work: This study aims to determine the utility of gadoxetic acid-enhanced MRI as a non-invasive, imaging-based method for evaluating regional liver function. Materials and Methods: In this retrospective analysis, 36 patients who underwent serial gadoxetic acid-enhanced MRI scans were included. Imaging was performed prior to and after portal vein embolization (PVE), as well as following extended right hemihepatectomy. Signal intensity (SI) and relative enhancement (RE) during the hepatobiliary phase were measured to determine the most reliable indicator of regional hepatic function. Results: A notable reduction in relative enhancement of the right liver lobe (RLL) was observed 14 days (RE = 0.49, P < 0.005) and 28 days post-PVE (RE = 0.50, P = 0.005), compared to pre-PVE levels (RE = 0.64). Conversely, the left liver lobe (LLL) exhibited a significant increase in RE 28 days post-PVE (RE = 0.70) compared to baseline (RE = 0.62, P = 0.040). Pearson correlation analysis demonstrated a significant positive relationship between LiMAx values and RE in the RLL before PVE (r = 0.452, P < 0.05), as well as in the LLL both pre-PVE (r = 0.399, P < 0.05) and postoperatively (r = 0.488, P < 0.05). Conclusion: Gadoxetic acid-enhanced MRI offers a reliable, imaging-based approach to assess regional liver function and can effectively estimate the functional reserve of hepatic segments. | ||||
| Keywords | ||||
| DCE-MRI Dynamic contrast-enhanced MRI; Gadoxetic acid-enhanced MRI; Future liver remnant volume; Liver function tests | ||||
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