Measurement of Regional Liver Function with Dynamic Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid-Enhanced Magnetic Resonance Imaging | ||
| International Journal of Medical Arts | ||
| Article 7, Volume 7, Issue 10, October 2025, Pages 6186-6192 PDF (1.46 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijma.2025.373335.2168 | ||
| Authors | ||
| Aboelyazid Elkilany* 1; Mohamed Saied Abdelgawad1; Mohamed Al-Warraky1; Timm Denecke2; Enas Mohamed Korayem1 | ||
| 1Department of Diagnostic and Interventional Medical Imaging, National Liver Institute, Menoufia University, Shebin Elkom, Menoufia, Egypt. | ||
| 2Department of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, Germany | ||
| Abstract | ||
| Background: Assessing regional liver function is crucial in patients scheduled for liver resection to support risk assessment and anticipate post-hepatectomy liver failure [PHLF]. The aim of the work: This study aimed to determine the utility of gadoxetic acid-enhanced MRI as a non-invasive, imaging-based method for evaluating regional liver function. Patients and Methods: In this retrospective analysis, 36 patients who underwent serial gadoxetic acid-enhanced MRI scans were included. Imaging was performed prior to and after portal vein embolization [PVE], as well as following extended right hemihepatectomy. Signal intensity [SI] and relative enhancement [RE] during the hepatobiliary phase were measured to determine the most reliable indicator of regional hepatic function. Results: A notable reduction in relative enhancement of the right liver lobe [RLL] was observed 14 days [RE = 0.49, P < 0.005] and 28 days post-PVE [RE = 0.50, P = 0.005], compared to pre-PVE levels [RE = 0.64]. Conversely, the left liver lobe [LLL] exhibited a significant increase in RE 28 days post-PVE [RE = 0.70] compared to baseline [RE = 0.62, P = 0.040]. Pearson correlation analysis demonstrated a significant positive relationship between LiMAx values and RE in the RLL before PVE [r = 0.452, P < 0.05], as well as in the LLL both pre-PVE [r = 0.399, P < 0.05] and postoperatively [r = 0.488, P < 0.05]. Conclusion: Gadoxetic acid-enhanced MRI offers a reliable, imaging-based approach to assess regional liver function and can effectively estimate the functional reserve of hepatic segments. | ||
| Keywords | ||
| Dynamic contrast-enhanced MRI; Gadoxetic acid-enhanced MRI; Future liver remnant volume; Liver function tests | ||
|
Statistics Article View: 229 PDF Download: 11 |
||
