Serum Level of Calprotectin and High Sensitive C-Reactive Protein in Patients with Psoriatic Arthritis and Their Relation to The Severity of the Disease
Mohammed, F., Elbiely, A., Hamed, Z., Abd El Rahim, M. (2025). Serum Level of Calprotectin and High Sensitive C-Reactive Protein in Patients with Psoriatic Arthritis and Their Relation to The Severity of the Disease. EKB Journal Management System, 2025(2), 232-237. doi: 10.21608/aimj.2025.446445
Fatma Magdy Mohammed; Adel Abbas Elbiely; Zhraa Nabil Hamed; Marwa Mohamed M. Ali Abd El Rahim. "Serum Level of Calprotectin and High Sensitive C-Reactive Protein in Patients with Psoriatic Arthritis and Their Relation to The Severity of the Disease". EKB Journal Management System, 2025, 2, 2025, 232-237. doi: 10.21608/aimj.2025.446445
Mohammed, F., Elbiely, A., Hamed, Z., Abd El Rahim, M. (2025). 'Serum Level of Calprotectin and High Sensitive C-Reactive Protein in Patients with Psoriatic Arthritis and Their Relation to The Severity of the Disease', EKB Journal Management System, 2025(2), pp. 232-237. doi: 10.21608/aimj.2025.446445
Mohammed, F., Elbiely, A., Hamed, Z., Abd El Rahim, M. Serum Level of Calprotectin and High Sensitive C-Reactive Protein in Patients with Psoriatic Arthritis and Their Relation to The Severity of the Disease. EKB Journal Management System, 2025; 2025(2): 232-237. doi: 10.21608/aimj.2025.446445

Serum Level of Calprotectin and High Sensitive C-Reactive Protein in Patients with Psoriatic Arthritis and Their Relation to The Severity of the Disease

Al-Azhar International Medical Journal
Volume 2025, Issue 2, February 2025, Page 232-237  XML PDF (454.91 K)
Document Type: Original Article
DOI: 10.21608/aimj.2025.446445
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Authors
Fatma Magdy Mohammed1; Adel Abbas Elbiely1; Zhraa Nabil Hamed2; Marwa Mohamed M. Ali Abd El Rahim1
1Rheumatology and Rehabilitation, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
2Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
Abstract
Background: Psoriatic arthritis (PsA) is defined as an inflammatory arthropathy correlated with psoriasis and is a member of the spondyloarthropathy family. Laboratory assessments for PSA, which involve C-reactive protein and erythrocyte sedimentation rate, often fail to provide accurate indicators of illness activity.
Aim: To assess the serum calprotectin and hs-CRP concentrations in PsA cases and to explore their potential relations to disease activity, skin affection and musculoskeletal US findings.
Patients and methods: The present research involved 55 PsA cases and 30 healthy subjects as a control. All subjects underwent medical history, musculoskeletal examination, ultrasound of hand and wrist joints, lower limb enthesis, and laboratory assessment.
Results: Serum CALP and hs-CRP concentrations were significantly elevated in PsA cases compared to the control group (p-value<0.05). Both markers were positively associated with PASI, DAPSA-28 and US scores, demonstrating their association with disease activity. Receiver Operating characteristic analysis identified optimal cut-off values (˃144 ng/ml for CALP and ˃1.63 milligram per liter for hs-CRP with high specificity and sensitivity.
Conclusion: Serum calprotectin and hs-CRP are promising biomarkers for assessing PsA disease activity, particularly in musculoskeletal and skin involvement. Their integration into routine clinical assessments may enhance disease monitoring and therapeutic decision-making.
Keywords
PsA; Calprotectin; hs-CRP; disease activity; US
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