Comparison Between Propofol–Ketamine and Propofol–Thiopentone as a Sedative agent for bone marrow biopsy procedures | ||
| Medicine Updates | ||
| Articles in Press, Accepted Manuscript, Available Online from 10 August 2025 PDF (810.51 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/muj.2025.405955.1238 | ||
| Authors | ||
| Nashwa Ahmed* 1; Reham Halem2; Mohamed Nassar3 | ||
| 1Lecturer of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Port Said University, Egypt | ||
| 2Professor of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Egypt. | ||
| 3Department of Anesthesia and surgical intensive care, Faculty of Medicine, Alexandria University, Egypt | ||
| Abstract | ||
| Background: Sedation and analgesia are currently commonly utilized for diverse types of short duration interventions as bone marrow biopsy. Aim: Comparing propofol -ketamine versus propofol-thiopentone regarding recovery and hemodynamic steadiness. Materials and Methods: This prospective randomized study incorporated thirty patients between 18-70 years old, divided into two equivalent groups randomly by closed envelope technique. Group propofol-thiopentone (PT): they were given propofol 1% and thiopentone 2.5% mixture in the ratio 10 ml (100 mg) to 10 ml (250 mg), in single syringe. Group propofol-ketamine (PK): they were given propofol 1% and ketamine 0.5% mixture in the ratio 10 ml (100 mg) to 10 ml (50 mg), in single syringe. Heart rate and Mean blood pressure had been recorded preoperatively and at end of the procedure (procedure take only 10 minutes.) also four-point scale was used to assess injection pain. The Modified Aldrete Score was used for assessment of Recovery from sedation after 10 minutes, after the procedure end. Results: In Group PT, Mean blood pressure and Heart rate values were 80.67±8.902 and 76.93±10.559 respectively, while in Group PK, were 79.67±9.263 and 78.93±8.548 respectively. Moreover, recovery scores were (15.00) in Group PT, while being (16.00) in Group PK. Pain scale was (16.50) in Group PT, while in Group PK was (14.50). there was no statistical differences between the two groups regarding mean blood pressure, Heart rate, pain on injection and recovery. Conclusions: When comparing propofol–thiopentone and propofol–ketamine combinations, both demonstrate effective hemodynamic stability, , without affecting recovery | ||
| Keywords | ||
| thiopentone; propofol; ketamine; hemodynamic; recovery | ||
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