Pleuropulmonary Features in Connective Tissue Diseases | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2025, Issue 2, February 2025, Page 289-293 PDF (317.88 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/aimj.2025.446454 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohamed Sedky Elsayed Mousa1; Houssam Eldin Hassanin Abd Elnaby1; Hany Mohamed Aly2; Ahmed Ali Mohamed Ali Ibrahim  1
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| 1Chest Diseases, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt | ||||
| 2Rheumatology and Rehabilitation, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Pleuropulmonary involvement could be noticed in almost all connective tissue diseases (CTDs), often next to articulo-skeletal manifestations. Therefore, early detection of respiratory affection is pivotal for the prognosis, since such involvement may boost morbidity and mortality. Aim of the work: To recognize the frequency and outcome of pleuropulmonary features in CTD patients, alongside investigating their correlations with the duration of the disease. Patients and methods: This cross-sectional study was conducted on forty patients with respiratory symptoms. They were all known as definitive CTD cases, and scheduled for follow-up at the rheumatology outpatient clinic in Al-Hussein University Hospital. Results: Pulmonary hypertension (PHTN) and interstitial lung disease (ILD) were the most frequent styles of pleuropulmonary involvement in CTD (45% and 35%, respectively). Pleural effusion showed a statistically significant good clinical outcome. Whereas, all patterns of parenchymal involvement (except lung abscess and rheumatoid nodule), pyopneumothorax and PHTN were associated with statistically significant unfavourable clinical outcome. ILD, lung cancer and PHTN displayed a statistically significant positive correlation with CTD duration. However, pleural effusion showed a statistically significant negative correlation with the same term. Conclusion: A wide variety of pleuropulmonary features in CTD patients occurs in the form of parenchymal affection and PHTN. Risk factors for poor clinical outcome in the context of CTD include ILD, pneumonia, lung cancer, diffuse alveolar hemorrhage (DAH), pyopneumothorax and PHTN. Longer CTD duration is positively correlated with ILD, lung cancer and PHTN. | ||||
| Keywords | ||||
| Pleuropulmonary; Connective tissue disease | ||||
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