Thyroid-Stimulating Hormone and Its Impact on Coronary Artery Disease and Left Ventricular Function | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2025, Issue 1, January 2025, Page 250-257 PDF (416.54 K) | ||||
| Document Type: Original Article | ||||
| DOI: /10.21608/aimj.2025.446463 | ||||
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| Authors | ||||
| Hanaa Mahmoud Mohammad Abdelaziz; Mohammed Fikry Mohammed Abdelrahman; Eid Mohamed Mohamed Abou El Maaty Daoud; Sally Magdy Teima | ||||
| Cardiovascular Medicine, Faculty of Medicine, Mansoura University, Daqahlya, Egypt | ||||
| Abstract | ||||
| Background: Globally, morbidity and mortality are primarily caused by coronary artery disease (CAD). Thyroid dysfunction is one of the cardiovascular risk factors that are frequently linked to CAD. The impact of thyroid-stimulating hormone (TSH) on left ventricular (LV) function and coronary artery disease (CAD) remains underexplored. Objectives: To examine the association between serum levels of thyroid stimulating hormone (TSH), the existence and degree of coronary artery disease (CAD) in patients referred for coronary angiography, and the effect of this relationship on left ventricular function. Methods: This cross-sectional analytic study was conducted on 50 CAD patients performing coronary angiography. Patients were categorized according to TSH values and the existence of severe coronary artery stenosis. Echocardiographic parameters, SYNTAX score, and TSH levels were assessed. Results: In comparison to the non-significant CAD group, the significant CAD group had a higher SYNTAX score (22.07 ± 13.6, p < 0.001) and a lower LV ejection fraction (EF) (56.0 ± 6.67, p=0.020). In the substantial CAD group, TSH levels were significantly higher (3.98 ± 2.6, p=0.009). EF was substantially lower (54.73 ± 6.90, p=0.002) and the SYNTAX score was higher (19.8 ± 15.1, p=0.002) in the group with raised TSH. EF and the Tei index (r=-0.316, p=0.025), as well as the SYNTAX score (r=-0.302, p=0.033), showed a strong negative association. Conclusions: Impaired LV function and more severe CAD are linked to elevated TSH levels. TSH may be a helpful marker for determining which patients are more likely to have severe CAD and reduced left ventricular function. | ||||
| Keywords | ||||
| Thyroid-Stimulating Hormone; Coronary Artery Disease; Left Ventricular Function | ||||
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