HOTAIR Long Non-Coding RNA Expression in Genital Warts Patients in Suez Canal Area | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2025, Issue 1, January 2025, Page 276-281 PDF (319.58 K) | ||||
| Document Type: Original Article | ||||
| DOI: /10.21608/aimj.2025.446467 | ||||
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| Authors | ||||
| Hany Mohamed Saad1; Moustafa Mohamed Kamel Eyada2; Mostafa Mahmoud El Desouky Saleh3; Noha M. Abd El-Fadeal4 | ||||
| 1Andrology, Infertility and STDs, Faculty of Medicine, Suez Canal University, Ismailia,Egypt | ||||
| 2Dermatology, Venerology and Andrology Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||||
| 3Dermatology in Mansoura Dermatology, Venereology and Leprosy Hospital Ministry of health and population, Cairo, Egypt | ||||
| 4Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Suez Canal University (SCU), Ismailia, Egypt , and ,Biochemistry, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia | ||||
| Abstract | ||||
| Background: Anogenital warts (AGWs) are a prevalent, highly transmittable illness induced by the human papillomavirus (HPV), with elevated rates of recurrence leading to direct medical costs, diminished productivity, and heightened psychosocial effects. Objectives: This research aimed to assess the level of expression of HOTAIR Long noncoding RNA in genital wart cases with an emphasis on its diagnostic values. Patients and Methods: This case control research has been conducted on sixty persons that have been recruited from the Dermatology and Andrology Outpatient Clinic of the Suez Canal University Hospitals. Only those with anogenital warts (AGW) have been involved. They have been separated into two groups: Group A (case group): 30 cases with genital warts, Group B (control group): 30 healthy volunteers. Results: A statistically significant distinction (p-value less than 0.05) has been observed among HOTAIR Long noncoding RNA expression in lessional tissue and normal tissue. Correlation between the size of the lesion and HOTAIR gene expression level in the diseased tissue (p-value <0.05) may be used as a marker for the severity of AGW. Conclusion: Our findings revealed that the expression of the HOTAIR gene, an oncogenic long noncoding RNA, is significantly higher in AGWs tissue relative to adjacent normal tissue. This suggests that circulating HOTAIR is a potential biomarker for the early diagnosis of AGWs, and this lncRNA may serve as a promising treatment target. | ||||
| Keywords | ||||
| Genital warts; sexually transmitted diseases; human papillomaviruses | ||||
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