Fractional Carbon Dioxide Laser Assisted Delivery of Tranexamic Acid Versus Ascorbic Acid in Treatment of Melasma, A Split Face Comparative Study with Digital Skin Analysis | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2025, Issue 1, January 2025, Page 288-294 PDF (510.19 K) | ||||
| Document Type: Original Article | ||||
| DOI: /10.21608/aimj.2025.446469 | ||||
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| Authors | ||||
| Bayoumy Ibrahim Abd-El Hameed Eissa; Amr Mohammad Ahmed Mahmoud Ammar; Omar Ahmed Abdelfattah Saleem Shoaib* | ||||
| Dermatology, Venereology and Andrology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Melasma is characterized as a brownish-red facial pigmentation that is blotchy and appears on both cheeks and forehead. Aim and objectives: Comparing the safety and effectiveness of using a fractional CO2 laser in conjunction with topical tranexamic acid vs ascorbic acid in the treatment of melasma. Patients and methods: Forty individuals, spanning the ages of 20 to 50, diagnosed with melasma were included in this prospective split-face comparison investigation. From May 2023 through September 2024, patients were enrolled in the dermatology outpatient clinics at Al-Azhar University Hospitals. Results: Treatment resulted in noticeably higher mean melanin and masi scores on the L-side compared to the R-side (P=0.04 and P=0.002, respectively). Conclusion: For melasma, the best treatment is a combination of low-power fractional CO2 and post-laser TXA or vitamin C; however, TXA works better in resistant instances. | ||||
| Keywords | ||||
| Fractional CO2 laser; Tranexamic acid; Ascorbic acid; Melasma; Digital skin analysis | ||||
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