Correlation between High Myopia and Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 144, Volume 100, Issue 1, July 2025, Page 3541-3548 PDF (646.09 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2025.446806 | ||||
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| Abstract | ||||
| Background: Emerging evidence suggests inflammation plays a significant role in the pathogenesis of high myopia, a globally escalating ocular condition. Myopic eye elongation is hypothesized to trigger oxidative stress, activating various inflammatory pathways. Aim: This study investigates the clinical correlation between high myopia and systemic inflammation using neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), which are novel, accessible, and cost-effective inflammatory biomarkers. Patients and Methods: This prospective, non-randomized, case-control cross-sectional study enrolled 80 participants: 40 with high myopia (axial length >26 mm or refraction >-6.0 D) and 40 normal emmetropic controls. High myopes were rigorously screened to exclude other ocular or systemic diseases that might affect NLR or PLR. All participants underwent comprehensive ocular examinations and peripheral blood tests. Results: Analysis revealed a significant positive correlation between high myopia and both NLR and PLR (p < 0.001 for both markers). Axial length (AL) also correlated significantly with NLR (r=0.40, P<0.001) and PLR (r=0.349, P=0.002). The Receiver operating characteristic (ROC) curve analysis identified NLR's optimal cutoff at 1.775 (70% sensitivity, 65% specificity), and PLR's at 99.8 (80% sensitivity, 52.5% specificity). Conclusion: Our findings strongly suggest that high myopia is associated with systemic inflammation, evidenced by elevated NLR and PLR. This supports the hypothesis of inflammatory processes contributing to myopia's pathophysiology. | ||||
| Keywords | ||||
| High myopia; Neutrophil to lymphocyte ratio; Platelet to lymphocyte ratio; Systemic inflammation | ||||
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