Antimicrobial resistance in agricultural settings: A One Health Approach to understanding cross-sectoral transmission and clinical implications
Zakari, D., Nwakile, C., Izuakor, C., Akarugwo, A., Tettok, N., Okpe, C., Okwo, C., Comfort, A., Mary, A., Audu, G., Okpanachi, C., Audu, G. (2025). Antimicrobial resistance in agricultural settings: A One Health Approach to understanding cross-sectoral transmission and clinical implications. EKB Journal Management System, (), -. doi: 10.21608/mid.2025.397479.2947
David Adeiza Zakari; Collins Toochukwu Nwakile; Chiamaka Fransisca Izuakor; Anene Ejike Akarugwo; Nicholas Irmiya Tettok; Chinyere Eucharia Okpe; Chinyere Eucharia Okwo; Ameh Honest Comfort; Ani Oluwatoyin Mary; Godwin Amoka Audu; Clifford Baba Okpanachi; Godwin Omuya Audu. "Antimicrobial resistance in agricultural settings: A One Health Approach to understanding cross-sectoral transmission and clinical implications". EKB Journal Management System, , , 2025, -. doi: 10.21608/mid.2025.397479.2947
Zakari, D., Nwakile, C., Izuakor, C., Akarugwo, A., Tettok, N., Okpe, C., Okwo, C., Comfort, A., Mary, A., Audu, G., Okpanachi, C., Audu, G. (2025). 'Antimicrobial resistance in agricultural settings: A One Health Approach to understanding cross-sectoral transmission and clinical implications', EKB Journal Management System, (), pp. -. doi: 10.21608/mid.2025.397479.2947
Zakari, D., Nwakile, C., Izuakor, C., Akarugwo, A., Tettok, N., Okpe, C., Okwo, C., Comfort, A., Mary, A., Audu, G., Okpanachi, C., Audu, G. Antimicrobial resistance in agricultural settings: A One Health Approach to understanding cross-sectoral transmission and clinical implications. EKB Journal Management System, 2025; (): -. doi: 10.21608/mid.2025.397479.2947

Antimicrobial resistance in agricultural settings: A One Health Approach to understanding cross-sectoral transmission and clinical implications

Microbes and Infectious Diseases
Articles in Press, Accepted Manuscript, Available Online from 11 August 2025  XML
Document Type: Review Article
DOI: 10.21608/mid.2025.397479.2947
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Authors
David Adeiza Zakariorcid 1; Collins Toochukwu Nwakile2; Chiamaka Fransisca Izuakororcid 3; Anene Ejike Akarugwo2; Nicholas Irmiya Tettok4; Chinyere Eucharia Okpe5; Chinyere Eucharia Okwo email 2; Ameh Honest Comfort6; Ani Oluwatoyin Mary2; Godwin Amoka Auduorcid 1; Clifford Baba Okpanachi7; Godwin Omuya Audu8
1Kogi state university, PMB 1008, Anyigba, Kogi state, Nigeria
2Department of Agricultural Education, University of Nigeria, Nsukka
3Department of Agricultural Education Nnamdi Azikiwe University, Awka
4DEPARTMENT OF AGRIC EDUCATION, FEDERAL UNIVERSITY OF EDUCATION PANKSHIN, PLATEAU STATE
5Department of Agricultural Education University of Nigeria, Nsukka
6Department of Animal Science University of Nigeria, Nsukka
7Department of pure and industrial chemistry, Prince Abubakar Audu University, PMB 1008, Anyigba, Kogi state
8department of microbiology, Prince Abubakar Audu University, PMB 1008, Anyigba, Kogi state
Abstract
Background: Antimicrobial resistance (AMR) represents one of the most pressing global health challenges of the 21st century, with agricultural practices playing a pivotal role in its development and dissemination. The extensive use of antimicrobials in livestock production, aquaculture, and crop protection has created selective pressure that drives the evolution and spread of resistant pathogens across the food chain. This review examines the complex interconnections between agricultural antimicrobial use and clinical medicine through a One Health lens, highlighting the mechanisms of resistance development, transmission pathways from farm to fork, and the clinical implications for human health. We discuss the emergence of multidrug-resistant organisms in agricultural settings, their potential for zoonotic transmission, and the impact on treatment efficacy in clinical practice. The review also addresses current surveillance systems, regulatory frameworks, and intervention strategies aimed at mitigating AMR spread from agricultural sources. Understanding these interconnections is crucial for developing comprehensive strategies that balance agricultural productivity with public health protection, emphasizing the need for coordinated action across human, animal, and environmental health sectors.
Keywords
antimicrobial resistance; agriculture; One Health; zoonotic transmission; food safety
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