Poly (lactic-co-glycolic acid) in Wound Repair: A Multifunctional Platform for Targeted Drug Delivery and Tissue Regeneration. | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Articles in Press, Accepted Manuscript, Available Online from 12 August 2025 | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/bfsa.2025.402978.2635 | ||||
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| Authors | ||||
Khaled E. Abuelella   1; Saadalla Nady Gaid2; Ahmed Abd El-Moniem Amer3
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| 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, 6th of October City, Giza 12585, Egypt. | ||||
| 2Department of Chemistry, Faculty of Pharmacy, October 6 University, 6th of October City, Giza 12585, Egypt. | ||||
| 3Pharmacist, Egyptian Drug Authority, Damanhur, Egypt | ||||
| Abstract | ||||
| Wound healing represents a highly complicated physiological process characterized by the coordinated spatial and temporal interaction of multiple cellular populations, each contributing distinct functions across the sequential phases of hemostasis, inflammation, proliferation, re-epithelialization, and tissue remodelling. Recent advancements in single-cell analytical technologies have facilitated the identification of significant phenotypic and functional heterogeneity among these cellular subsets, providing novel insights into their specific roles and dynamic contributions throughout the healing cascade. Poly (lactic-co-glycolic acid) (PLGA), a synthetic copolymer of lactic acid and glycolic acid, has been extensively investigated in biomedical research owing to its favorable biocompatibility, biodegradability, and regulatory acceptance by Food and Drug Administration (FDA). This review provides a comprehensive overview of the applications of PLGA based drug delivery systems in wound healing, emphasizing their capacity to encapsulate and stabilize various bioactive agents, including antibiotics, anti-inflammatory drugs, proteins, peptides, and nucleic acids, across various phases of the wound healing cascade. Furthermore, recent findings suggesting an inherent pro-regenerative effect of PLGA beyond its function as a delivery vehicle are critically examined. By integrating current preclinical and translational data, the review highlights the therapeutic potential of PLGA-based nanoparticles, microspheres, nanofibers and hydrogels for the management of complex dermal injuries. | ||||
| Keywords | ||||
| PLGA; wound healing; microspheres; nanofibers; hydrogel | ||||
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