Assessment of CA 19-9 in Patients with Thyroid Malignancies | ||||
| Sohag Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 13 August 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/smj.2025.380939.1563 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Amany Abbas Abdel Allah  1; Laila Mohamed Yousef2; Marwa Ashraf Youssif3; Mohammed ElRawey4
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| 1Department of Clinical Pathology,Faculty of Medicine, Sohag University. | ||||
| 2Department of Clinical Pathology, Faculty of Medicine, Sohag University. | ||||
| 3Clinical Pathology Department, Sohag Oncology Center, Ministry of Health, Sohag, Egypt | ||||
| 4Clinical Pathology, Sohag university | ||||
| Abstract | ||||
| Background: Carbohydrate antigen 19-9 (CA 19-9) is a cell surface glycoprotein complex that is used as a tumor marker for pancreatic and biliary malignancies. Its significance in thyroid cancer is controversy. However some studies demonstrated that CA19-9 is expressed in both differentiated and anaplastic thyroid carcinomas. Objectives: 1.The aim of this work was to investigate the relationship between levels of CA 19-9 and thyroid malignancies. 2. The relation between CA19-9 and prognosis of the disease. Methods: This case-control study was carried out on 120 subjects; 40 healthy individuals as control (Group I), 40 patients with localized thyroid cancer (Group II) and 40 patients with metastatic thyroid cancer (Group III). CA19.9 was measured in all patients. Results: Ca19-9 show significant increase in group II, III as compared to group I (P <0.001). There is significant increase in medullary and follicular thyroid cancer in group III as compared to group II (P= 0.002). CA19-9 with cut off (>11.1); showed 87.5% sensitivity, 100% specificity and 97.4% accuracy. Conclusions: Elevation of CA19-9 with thyroid malignancy is a sign of bad prognosis which require special care of diagnosis and treatment to be capable of overcoming the serious illness. | ||||
| Keywords | ||||
| CA 19-9; Thyroid Malignancies; Medullary Thyroid Carcinoma; Papillary Carcinoma; Follicular Carcinoma | ||||
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