ASSESSMENT OF THE ROLE OF NON-CLASSICAL HUMAN LEUCOCYTIC ANTIGENS A-G (HLA-G) VARIATIONS ON HYDATID DISEASE | ||
| Journal of the Egyptian Society of Parasitology | ||
| Volume 55, Issue 2, August 2025, Pages 217-224 PDF (339.4 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2025.447398 | ||
| Authors | ||
| NAYERA S. ATEEQ* 1; EMAN M. HUSSEIN2; NEHAL S. YAHAI3; SHERINE ELZAGAWY4 | ||
| 1Department of Medical Parasitology, Suez Canal University, Ismailia Governorate, Egypt | ||
| 2Department of Medical Parasitology, Suez Canal University, Ismailia Governorate, Egypt. | ||
| 3Department of Diagnostic Radiology, Faculty of Medicine, Suez Canal University, Ismailia Governorate, Egypt. | ||
| 4Department of Medical Parasitology, Suez Canal University, Ismailia Governorate, Egypt. | ||
| Abstract | ||
| In Egypt, cystic echinococcosis (CE) is a public health problem that categorizes patients into susceptible or resistant groups referring to the immune system, particularly human leukocytic antigen (HLA) Class I & II. In the present study, relation between non-classical HLA -G alleles and the CE was achieved in a retrospective case-control study in Ismailia province. The study included 33 diseased and Control groups matching age, sex, and residence. To identify HLA-G alleles, Polymerase Chain Reaction (PCR) was performed. The frequency of non-classical HLA-G alleles indicated a significant difference between the two study groups in only two (0103 and 0105) out of seven. Allele 0103 was absent in 17 out of 33 (54.5%) patients, while it lacked in 2 control persons (6.1%), however the allele 0105 was lacking in 16 out of 33 (48.5%) patients, while it missed in 3 control persons (9.1%). Regarding cyst sizes, < 5 cm and ≥ 5 cm showed significant differences. There were no significant differences in HLA-G distri bution concerning the affected organs. | ||
| Keywords | ||
| Hydatid cyst; HLA-G; Genotyping; Cyst | ||
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