ASSESSMENT OF THE ROLE OF NON-CLASSICAL HUMAN LEUCOCYTIC ANTIGENS A-G (HLA-G) VARIATIONS ON HYDATID DISEASE
ATEEQ, N., HUSSEIN, E., YAHAI, N., ELZAGAWY, S. (2025). ASSESSMENT OF THE ROLE OF NON-CLASSICAL HUMAN LEUCOCYTIC ANTIGENS A-G (HLA-G) VARIATIONS ON HYDATID DISEASE. EKB Journal Management System, 55(2), 217-224. doi: 10.21608/jesp.2025.447398
NAYERA S. ATEEQ; EMAN M. HUSSEIN; NEHAL S. YAHAI; SHERINE ELZAGAWY. "ASSESSMENT OF THE ROLE OF NON-CLASSICAL HUMAN LEUCOCYTIC ANTIGENS A-G (HLA-G) VARIATIONS ON HYDATID DISEASE". EKB Journal Management System, 55, 2, 2025, 217-224. doi: 10.21608/jesp.2025.447398
ATEEQ, N., HUSSEIN, E., YAHAI, N., ELZAGAWY, S. (2025). 'ASSESSMENT OF THE ROLE OF NON-CLASSICAL HUMAN LEUCOCYTIC ANTIGENS A-G (HLA-G) VARIATIONS ON HYDATID DISEASE', EKB Journal Management System, 55(2), pp. 217-224. doi: 10.21608/jesp.2025.447398
ATEEQ, N., HUSSEIN, E., YAHAI, N., ELZAGAWY, S. ASSESSMENT OF THE ROLE OF NON-CLASSICAL HUMAN LEUCOCYTIC ANTIGENS A-G (HLA-G) VARIATIONS ON HYDATID DISEASE. EKB Journal Management System, 2025; 55(2): 217-224. doi: 10.21608/jesp.2025.447398

ASSESSMENT OF THE ROLE OF NON-CLASSICAL HUMAN LEUCOCYTIC ANTIGENS A-G (HLA-G) VARIATIONS ON HYDATID DISEASE

Journal of the Egyptian Society of Parasitology
Volume 55, Issue 2, August 2025, Page 217-224  XML PDF (339.4 K)
Document Type: Original Article
DOI: 10.21608/jesp.2025.447398
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Authors
NAYERA S. ATEEQ email 1; EMAN M. HUSSEIN2; NEHAL S. YAHAI3; SHERINE ELZAGAWY4
1Department of Medical Parasitology, Suez Canal University, Ismailia Governorate, Egypt
2Department of Medical Parasitology, Suez Canal University, Ismailia Governorate, Egypt.
3Department of Diagnostic Radiology, Faculty of Medicine, Suez Canal University, Ismailia Governorate, Egypt.
4Department of Medical Parasitology, Suez Canal University, Ismailia Governorate, Egypt.
Abstract
In Egypt, cystic echinococcosis (CE) is a public health problem that categorizes patients into 
susceptible or resistant groups referring to the immune system, particularly human leukocytic 
antigen (HLA) Class I & II. In the present study, relation between non-classical HLA -G alleles 
and the CE was achieved in a retrospective case-control study in Ismailia province. The study 
included 33 diseased and Control groups matching age, sex, and residence. To identify HLA-G 
alleles, Polymerase Chain Reaction (PCR) was performed. The frequency of non-classical 
HLA-G alleles indicated a significant difference between the two study groups in only two 
(0103 and 0105) out of seven. Allele 0103 was absent in 17 out of 33 (54.5%) patients, while it 
lacked in 2 control persons (6.1%), however the allele 0105 was lacking in 16 out of 33 
(48.5%) patients, while it missed in 3 control persons (9.1%). Regarding cyst sizes, < 5 cm and 
≥ 5 cm showed significant differences. There were no significant differences in HLA-G distri
bution concerning the affected organs.  
Keywords
Hydatid cyst; HLA-G; Genotyping; Cyst
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