Ovarian Function Preservation in Premenopausal Cancer Patients on Chemotherapy | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 155, Volume 100, Issue 1, July 2025, Page 3629-3634 PDF (600.36 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2025.447684 | ||||
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| Abstract | ||||
| Background: Cancer therapies can negatively affect ovarian function, making fertility preservation a key concern for young patients. Gonadotropin-releasing hormone agonists (GnRHa) provide a non-surgical option for women who are unable to pursue or decline other fertility preservation techniques. Objectives: This study aimed to evaluate the impact of using GnRHa alongside chemotherapy in breast cancer patients of childbearing age. Patients and methods: This retrospective cohort study was conducted at the Oncology Center Mansoura University (OCMU). It included 30 patients with breast cancer. All participants underwent detailed medical history, physical examinations, and a range of laboratory and radiological investigations. Pathological assessments included evaluating ER, PR, Her-2neu status, Ki67, and FSH/E2 levels. Results: Of the patients studied, 96% (26 of 27) regained regular menstruation, with 16 cases resuming menses within six months of chemotherapy. Three patients had unknown data due to hormonal pill use. One 45-year-old patient experienced amenorrhea with postmenopausal FSH and E2 levels. Two out of nine patients (22.2%) who tried to conceive achieved a full-term pregnancy. The 24 patients (80%) who did not conceive cited various reasons including being unmarried (16.6%), having completed their family (54.1%), local recurrence (12.5%), distant metastasis (4.1%), and actively seeking fertility (12.5%). Conclusion: Using GnRHa with chemotherapy appears beneficial for fertility preservation, although efficacy varies with cancer type, treatment, and individual patient factors. This highlighted GnRHa's role in mitigating chemotherapy-induced ovarian toxicity, particularly in patients on high-infertility-risk regimens. | ||||
| Keywords | ||||
| Premenopausal cancer; Ovarian function; Chemotherapy; Gonadotropin-releasing hormone | ||||
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