Evaluation of Serum Soluble Intercellular Adhesion Molecule 1 (sICAM1) as A Biomarker in Acne Vulgaris | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 160, Volume 100, Issue 1, July 2025, Page 3662-3666 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2025.447690 | ||||
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| Abstract | ||||
| Background: Acne vulgaris (AV) is an inflammatory disorder of the pilosebaceous unit, characterized by the development of papules, pustules, and nodules. Intercellular adhesion molecule-1 (ICAM1) is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily normally expressed at minimal levels in numerous cells but upregulated in response to several inflammatory agents. Objectives: This study aimed to assess and compare the serum levels of soluble ICAM1 in patients with AV to those in healthy controls (HC) and to correlate the level of ICAM-1 with disease activity. Patients and methods: The study included 40 patients with AV and 40 age- and sex-matched healthy volunteers as a control group. The assessment of disease severity was conducted using the Global acne grading system (GAGS). The serum concentrations of soluble intercellular adhesion molecule 1 were measured using enzyme-linked immunosorbent assay (ELISA). Results: The mean sICAM-1 level was significantly increased among AV cases compared to healthy controls. Mild acne was present in 15 cases, moderate acne among 15 cases and severe acne was present among 10 cases. Cases with severe AV were statistically significantly younger than those with mild and moderate acne. A significant positive correlation was detected between disease duration and acne severity. There was a significant association between sICAM-1 and the degree of acne severity. Median sICAM-1 levels were highest among severe cases, followed by moderate cases, and then mild cases. Conclusion: It could be concluded that serum sICAM-1 levels are higher in AV cases than in healthy controls and serve as an independent predictor of acne susceptibility and severity. | ||||
| Keywords | ||||
| Serum SICAM1; Acne Vulgaris | ||||
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