Study on Efficacy of Resveratrol in Treatment of Cryptosporidiosis in Experimentally Infected Mice | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 161, Volume 100, Issue 1, July 2025, Page 3667-3673 PDF (946.09 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2025.447691 | ||||
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| Abstract | ||||
| Background:Cryptosporidium is a zoonotic protozoan parasite causing cryptosporidiosis in humans and animals. It is a major diarrheal contributor in developing nations and the second leading cause of death in children under five. While Nitazoxanide is the standard treatment, its efficacy is modest in children and immunosuppressed individuals. Consequently, resveratrol is being investigated as a potential natural antiparasitic agent. Objectives: This experimental animal study represents a new trial to assess the anti-parasitic effect of resveratrol as a treatment for cryptosporidiosis in immunosuppressed mice, either on its own or in conjunction with nitazoxanide. Materials and methods: Fifty laboratory-bred male albino mice were orally infected with 3000 Cryptosporidium oocysts. These animals were then divided into two main groups. Group A served as the control, comprising a negative control subgroup (uninfected, untreated) and a positive control subgroup (infected, untreated). Group B consisted of infected mice that received treatment with either nitazoxanide, resveratrol, or a combination of both. Evaluation was conducted using parasitological and histopathological parameters. Results: All treated groups showed a significant reduction in the shedding of Cryptosporidium oocysts. The greatest reduction occurred in the group treated with a combination of nitazoxanide and resveratrol, followed by the group treated with resveratrol alone. The group treated with nitazoxanide showed the least reduction. Remarkable improvement of the histopathological findings was observed especially after receiving combined nitazoxanide & resveratrol followed by resveratrol treated group and then the nitazoxanide treated mice. Conclusion: Resveratrol can serve as an effective treatment for Cryptosporidium spp. infection, whether used on its own or in conjunction with nitazoxanide. | ||||
| Keywords | ||||
| Resveratrol; Nitazoxanide; Cryptosporidium | ||||
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