Functional Insights into The Role of LncRNA HOXA11-AS in Pancreatic Adenocarcinoma | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 162, Volume 100, Issue 1, July 2025, Page 3674-3679 PDF (640.92 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2025.447692 | ||||
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| Abstract | ||||
| Background: Pancreatic adenocarcinoma is one of the most lethal cancer charachterized by extremely poor prognosis and diagnosis. lncRNAs, which are transcripts exceeding 200 nucleotides, have recently emerged as new drivers of tumorigenesis. Objective: This study aimed to demonstrate the relation of the long non-coding RNA (lncRNA)—HOXA11-AS,—with the risk, pathological characteristics and survival rate of pancreatic adenocarcinoma. Subjects and Methods: A total of150 people included in this study: 75 pancreatic adenocarcinoma patients and 75 healthy individuals. Carcinoembryonic antigen (CEA) and CA19-9 were assayed using ELISA, while real-time PCR has been used for determination of the level of LncRNA HOXA11-AS (Homeobox (HOX) A11 antisense). Results: Compared to controls, pancreatic adenocarcinoma patients had statistically significant higher levels of HOXA11-As expression. Nearly half of cases were still alive at the end of the research, which proves that the disease has high death rate. Patients with low HOXA11-AS expression survived longer (18.0 months) on average compared to those with high expression (13.04 months). Conclusion: lncRNA HOXA11-AS may be utilized as diagnostic biomarker for pancreatic adenocarcinoma. Pancreatic adenocarcinoma has poor survival . CEA and CA19-9 are also significantly elevated in pancreatic adenocarcinoma. | ||||
| Keywords | ||||
| Carbohydrate antigen19-9; Carcinoembryonic antigen; Pancreatic cancer; pancreatic adenocarcinoma; Long non coding RNA | ||||
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