Dual-Energy X-ray Absorptiometry and Bone Densitometry in CKD Children on Regular Haemodialysis | ||||
| Zagazig University Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 17 August 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2025.404927.4057 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Seham Mohammed Ibrahim Ramadan1; Ezzat k. Amin2; Esraa Attia Ebrahim Hassan  3; Mohamed Ibrahim Amin4; Eman Mohammed Abdel Hady 1
| ||||
| 1Lecturer of Pediatrics, Faculty of Medicine, Zagazig University | ||||
| 2Professor of Pediatrics, Faculty of Medicine, Zagazig University | ||||
| 3MBBCH, Faculty of Medicine, Zagazig University | ||||
| 4Professor of Radiodiagnosis, Faculty of Medicine, Zagazig University | ||||
| Abstract | ||||
| Background: Children who had chronic kidney disease (CKD) could be usually at high risk of disturbances in bone mineral metabolism, that could impair growth and increase fracture risk. Dual-energy X-ray absorptiometry (DEXA) could be considered as the gold standard evaluation tool for bone mineral density (BMD) among these patients. This study aimed to assess bone mineral density and body composition in children who had CKD and undergoing hemodialysis using DEXA. Methods: This cross-sectional study involved 39 children with CKD on regular hemodialysis at Zagazig University Children’s Hospital. All participants underwent comprehensive clinical assessment, laboratory investigations for mineral metabolism (calcium, phosphorus, parathyroid hormone (PTH), vitamin D, and DEXA scans of the lumbar spine and whole body. Results: The mean lumbar spine BMD was 0.63 ± 0.1 g/cm², with a median Z-score of +0.6; 43.6% had osteopenia (Z ≤ –1) and 7.7% had osteoporosis (Z ≤ –2.5). Higher PTH and phosphorus were significantly associated with lower BMD (p < 0.01), while higher calcium and vitamin D were associated with greater BMD (p < 0.05). Older age and longer dialysis duration correlated with higher BMD (p < 0.05). Conclusion: Metabolic factors, especially serum calcium, phosphorus, vitamin D, and PTH, were the strongest determinants of BMD in pediatric dialysis patients, outweighing demographic factors or dialysis duration. Regular DEXA screening and early management of mineral disturbances may help reduce fracture risk and improve bone health in this vulnerable group. | ||||
| Keywords | ||||
| Dual-Energy X-ray Absorptiometry; Bone Densitometry; Chronic Kidney Disease; Hemodialysis | ||||
|
Statistics Article View: 15 |
||||
