Immediate and Short-Term Outcome of Percutaneous Trans-Catheter Device Closure of Atrial Septal Defects in Adults | ||||
| Ain Shams Medical Journal | ||||
| Volume 76, Issue 2, June 2025, Page 353-364 PDF (477.96 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/asmj.2025.361421.1396 | ||||
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| Authors | ||||
Dina Ezzeldin  ; Ghada Elshahed; Eslam Ewais; Mohammad Saber Hafez
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| Cardiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Atrial septal defect (ASD), one of the most common congenital heart defects, often remains undiagnosed until adulthood, leading to complications like pulmonary hypertension, arrhythmias, and right ventricular (RV) dysfunction. Transcatheter ASD closure offers a minimally invasive option. Aim of the Work: To evaluate the immediate and short-term outcome of transcatheter ASD closure on cardiac functions and functional capacity in adults. Methods: This prospective cohort study included 50 adults who underwent transcatheter ASD closure. Patients were stratified according to age at transcatheter closure into two groups: Group 1 (18–40 years) and Group 2 (>40 years). Comprehensive pre- and post-procedural assessments included echocardiography, 6-minute walk test (6MWT), and coronary angiography. Results: Significant reductions in RV end-diastolic volume (75.20 ± 10.30 to 68.18 ± 9.98 mm3, P < 0.001), RV systolic pressure (49.22 ± 4.85 to 35.14 ± 4.77 mmHg, P < 0.0001), and mean pulmonary artery pressure (28.82 ± 6.43 to 23.86 ± 5.90 mmHg, P < 0.001) were observed at one month. Left ventricular ejection fraction improved significantly (P < 0.001), and 6-minute walk test (6MWT) distance increased (464.38 ± 49.61 to 488.80 ± 44.39 m, P < 0.001). Younger patients exhibited greater functional capacity improvement (P = 0.008). Pre-procedural mPAP negatively correlated with 6MWT performance (P < 0.05). Conclusions: Transcatheter ASD closure significantly improves cardiac remodeling, pulmonary hemodynamics, and functional capacity, with younger patients benefiting most. | ||||
| Keywords | ||||
| Atrial septal defect; echocardiography; functional capacity; pulmonary hemodynamics; transcatheter closure | ||||
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