Cord Blood Adropin as an early predictor for fetal Growth and Cardiac Complications in Infants of Diabetic Mothers | ||||
| Ain Shams Medical Journal | ||||
| Volume 76, Issue 2, June 2025, Page 381-389 PDF (371.82 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/asmj.2025.364053.1406 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Soha Khafagy1; Nancy Abu Shady1; Miral Ahmed1; Madona Zaki1; Dina Tharwat Ghanem   2; Mohamed Hussein Metwally3
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| 1Pediatrics Department ,Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
| 2Clinical pathology, Ain Shams University,cairo, Egypt | ||||
| 3Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Adropin is a polypeptide involved in energy homeostasis, insulin response, and endothelial function, significantly impacting fetal development. Numerous studies suggest that it regulates fetal growth. Aim of the Work: The current study sought to investigate cord blood adropin levels in infants of diabetic mothers and to correlate them with fetal growth, and cardiac complications. Patients and Methods: Thirty infants of mothers with diabetes mellitus (IDM) and thirty infants whose mothers did not have diabetes were enrolled in this comparative case-control study. Adropin levels were assayed by non-competitive enzyme- linked immunosorbent assay in the cord blood of all enrolled neonates. Birth weight and ponderal index were recorded. Echocardiographic measurements were conducted in the first three days of life. Results: Adropin levels were significantly lower in infants of diabetic mothers [median (IQR): 80.25 (55.5 – 99) pg/ml] compared to infants of non-diabetic mothers [ median (IQR): 718.25 (487-944)]. Growth-related metrics (including birth weight and ponderal index) and echocardiographic measurements of left ventricular end-systolic dimensions were negatively correlated with adropin levels. Conclusion: Cord blood adropin levels can be used as a foreteller of fetal growth and cardiac complications in infants of diabetic mothers. | ||||
| Keywords | ||||
| Diabetes Mellitus; echocardiography; marker; newborn | ||||
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