Predictive Value of Red Cell Distribution Width-to-Lymphocyte Ratio for Diagnosis of Post Hepatic Cirrhosis | ||||
| Ain Shams Medical Journal | ||||
| Volume 76, Issue 2, June 2025, Page 439-454 PDF (538.8 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/asmj.2025.353749.1371 | ||||
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| Authors | ||||
Sonya Ahmed Ali El-Gaaly   ; Essam Mohamed Bayoumi Hilal; Shaimaa Shazly Massoud; Mohamed Nabil Badawy Al-Ashram
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| Department of Gastroenterology and Hepatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: As a promising noninvasive biomarker for diagnosing chronic hepatic diseases, including post-hepatatic cirrhosis, the Red Cell Distribution Width-to-Lymphocyte Ratio (RDW-to-LR) has been emerged. Chronic liver diseases, such as post-hepatatic cirrhosis, are associated with impaired liver function and pose significant global health challenges. Traditional liver biopsy is invasive, highlighting the need for safer diagnostic approaches. Aim: This study goal is to evaluate the RDW-to-LR predictive value in diagnosing post-hepatatic cirrhosis and explore its potential mechanisms in reflecting pathophysiological modifications. Methods: The study perfomed on 60 hepatitis B patients from Ain Shams University Hospital, divided into three groups: 30 with HBV-related cirrhosis, 30 healthy controls, and 30 with chronic hepatitis B, and. Laboratory evaluations measured total bilirubin, liver enzymes (ALT, AST), GGT. Results: Regarding liver enzyme levels significant differences were found across the groups, with increased AST, ALT, and GGT in the hepatitis and cirrhosis groups. Correlation analysis showed RDW-to-LR's association with liver function parameters and its inverse relationship with hematological health indicators. Logistic regression identified RDW-to-LR as a significant predictor for cirrhosis. its high specificity and sensitivity in distinguishing cirrhosis from hepatitis and controls was confirmed via ROC analysis. Conclusion: This study supports for diagnosing HBV-related cirrhosis the RDW-to-LR as a noninvasive, reliable biomarker. | ||||
| Keywords | ||||
| Post hepatatic cirrhosis; red cell distribution; width-to-lymphocyte ratio | ||||
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