Serum Anti-Elastin Antibodies and Carotid Intima-Media Thickness as Indicators for Vascular Affection in Asthmatic Children | ||
| Ain Shams Medical Journal | ||
| Volume 76, Issue 2, June 2025, Pages 507-516 PDF (445.53 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/asmj.2025.356833.1389 | ||
| Authors | ||
| Eman Mahmoud Fouda1; Mariz Zakaria Adly* 2; Basma Sherif Fahmy3; Asaad Gamal Asaad1; Heba moustafa Hamza4 | ||
| 1Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||
| 2Pediatrics,faculty of medicine,ain shams university,cairo,egypt | ||
| 3Clinical Pathology, Faculty of Medicine, Ain Shams university, Cairo, Egypt | ||
| 4Department of Pediatrics, Faculty of Medicine, Ain Shams University | ||
| Abstract | ||
| Background: Asthma is associated with elevated cardiovascular disease risk, probably due to a common inflammatory pathophysiology. Objective: This study assessed serum anti-elastin antibodies and carotid intima-media thickness (CIMT) as systemic vascular changes in asthmatic children and its correlation with asthma severity and control. Patients and Methods: 70 children were enrolled in this prospective case-control study (35 asthmatic and 35 controls) from the Pediatric Pulmonology Unit, Children’s Hospital, Ain Shams University, Cairo. They were subjected to a detailed history taking, physical examination, the following investigations were done (CBC, CRP, serum IgE, serum Antielastin antibody as a marker for vascular inflammation, carotid intima-media thickness by doppler ultrasound). Results: Serum anti-elastin antibody levels were significantly higher in asthmatic group (69.11 ± 63.18 pg/ml) compared to control group (6.61 ± 3.68 pg/ml) (P-value < 0.001), with significantly higher level of serum anti-elastin antibodies in uncontrolled asthmatic children (91.16 ± 102.58 pg/ml) compared to controlled cases (51.05 ± 44.82 pg/ml) and partially controlled cases (68.85 ± 53.88 pg/ml) (p-value <0.001). A statistically significant positive correlation was discovered between serum IgE and anti-elastin antibodies (r= 0.774, p<0.001). Carotid intima-media thickness (CIMT) among asthmatic children was (right 0.050 ± 0.008 cm, left 0.051 ± 0.007 cm) compared to control group (right 0.048 ± 0.007 cm, left 0.048 ± 0.009 cm) with percentage of increase 4% in right carotid artery and 5.4% in left one. No significant difference in mean CIMT between the right and left sides among asthmatic children with different asthma control levels. Conclusion: Serum Anti-elastin antibodies a vascular inflammatory marker, were higher in asthmatic children compared to controls. This may require periodic follow up of any vascular changes in those patients. | ||
| Keywords | ||
| Asthmatic children; Antielastin antibody; carotid intima-media thickness | ||
|
Statistics Article View: 107 PDF Download: 38 |
||
