Canine and Feline Parvovirus in Egypt: Current Molecular Update | ||||
| Egyptian Journal of Veterinary Sciences | ||||
| Article 23, Volume 56, Issue 8, August 2025, Page 1909-1917 PDF (1.14 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejvs.2025.326575.2411 | ||||
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| Authors | ||||
Nehal Abdelhameed1; Noura Alkhalefa2; Ahmed Elsify3; Akram Salama 1; Ahmed Zaghawa4; Mohamed Nayel  1
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| 1Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Sadat City 32897, Menoufia, Egypt. | ||||
| 2Department of Virology, Faculty of Veterinary Medicine, Kafr Elsheikh University, Kafr Elsheikh 33516, Egypt. | ||||
| 3Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Menofia 32897, Egypt | ||||
| 4Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Sadat City 32897, Menoufia, Egypt. Faculty of Veterinary Medicine Sadat University | ||||
| Abstract | ||||
| Acute contagious enteritis with dramatic mortality and morbidity caused by canine parvovirus type 2. Although serious clinical illness often affects dogs older than six months, adults with compromised immune systems may also be affected. There is little information about the recent molecular changes in Canine Parvovirus 2 variants in Egypt. The present status of our understanding of Canine Parvovirus 2 variants mutations is reviewed in this article. A total of 200 rectal swabs were collected from Cairo, Giza, Alexandria, Matrouh, Gharbia, and Menoufia governorates during 2023-2024 from clinically suspected infected dogs and cats of different ages, breeds, genders, and vaccination status, with moderate to severe signs of enteritis, including bloody diarrhea, vomiting, fever, and inappetence. The viral DNA was identified in 168/200 (84%) samples by PCR; the phylogenetic analysis revealed circulating FPV, CPV-2a, and CPV-2c in examined areas. Nucleotide sequence analysis of (CPV2c/Egy1/CPV2) strain has different point mutations at positions (G106T), (A326G), (AAT493-495GAA), and (G535A). In comparison to the reference strains. While (FPV/Egy1/FPL) and (FPV/Egy2/FPL) had an additional nucleotides substitution at residue (A17T), (C48T), (G116C), (T130G), (C145G), (A185G). Our results revealed the prevalence of CPV-2 among Egyptian dogs and cats; further epidemiological and molecular studies on CPV-2 and FPV are extremely wanted, reinforcing the critical need for vaccination of all healthy dogs and cats against Parvoviruses. | ||||
| Keywords | ||||
| CPV; PCR; VP2 Sequencing; Phylogenetic Analysis; Egypt | ||||
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