Assessing Toxicity and Histopathological Effects of a Novel Group Acetyl-CoA Carboxylase Insecticides (Tetramic and Tetronic Acids-Based) Against Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae)
El-Shennawy, R., Kandel, M., El-Bassouiny, H., Selim, S. (2025). Assessing Toxicity and Histopathological Effects of a Novel Group Acetyl-CoA Carboxylase Insecticides (Tetramic and Tetronic Acids-Based) Against Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae). EKB Journal Management System, 17(2), 21-34. doi: 10.21608/eajbsf.2025.447945
Rania M. El-Shennawy; Mervat A.A. Kandel; Hisham M. El-Bassouiny; Shady Selim. "Assessing Toxicity and Histopathological Effects of a Novel Group Acetyl-CoA Carboxylase Insecticides (Tetramic and Tetronic Acids-Based) Against Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae)". EKB Journal Management System, 17, 2, 2025, 21-34. doi: 10.21608/eajbsf.2025.447945
El-Shennawy, R., Kandel, M., El-Bassouiny, H., Selim, S. (2025). 'Assessing Toxicity and Histopathological Effects of a Novel Group Acetyl-CoA Carboxylase Insecticides (Tetramic and Tetronic Acids-Based) Against Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae)', EKB Journal Management System, 17(2), pp. 21-34. doi: 10.21608/eajbsf.2025.447945
El-Shennawy, R., Kandel, M., El-Bassouiny, H., Selim, S. Assessing Toxicity and Histopathological Effects of a Novel Group Acetyl-CoA Carboxylase Insecticides (Tetramic and Tetronic Acids-Based) Against Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae). EKB Journal Management System, 2025; 17(2): 21-34. doi: 10.21608/eajbsf.2025.447945

Assessing Toxicity and Histopathological Effects of a Novel Group Acetyl-CoA Carboxylase Insecticides (Tetramic and Tetronic Acids-Based) Against Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae)

Egyptian Academic Journal of Biological Sciences, F. Toxicology & Pest Control
Volume 17, Issue 2, December 2025, Page 21-34  XML PDF (1.04 MB)
Document Type: Original Article
DOI: 10.21608/eajbsf.2025.447945
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Authors
Rania M. El-Shennawy1; Mervat A.A. Kandel1; Hisham M. El-Bassouinyorcid 1; Shady Selim2
1Bollworm Department, Plant Protection Research Institute, Agriculture Research Center, Dokki, Giza-Egypt.
2Pesticide Chemistry and Technology Department, Faculty of Desert and Environmental Agriculture, Matrouh University, Matrouh, Egypt
Abstract
In a laboratory study, this research focused on the effects of the insecticides spirodiclofen, spiromesifen, and spirotetramat, which are Acetyl-CoA carboxylase (ACC) inhibitors, on the mortality rates of Pectinophora gossypiella neonates. A comparative assessment of toxicity through contact and ingestion was conducted at 6, 12, 24, 48, and 72 hours. Results indicated that spirotetramat exhibited higher toxicity as the median lethal concentration (LC50) values significantly decreased over time (21.619 to 6.872 µg/ml). While spirodiclofen demonstrated moderate effectiveness, otherwise spiromesifen was considerably weaker, especially during the initial hours. Biological evaluation revealed prolonged larval developmental time and reduced weight in the treated larvae, with spirodiclofen causing the most significant effect. The highest mortality rate was observed for the spiromesifen treatment (81.7%), closely followed by spirodiclofen and spirotetramat (85.7% and 84.7%, respectively). There was a notable decrease in the pupation percentage and a significant increase in the pupal malformation percentage across all treatments compared to the control group. Histopathological examination revealed significant alterations in integument and gut structures, including degeneration of cuticle layers and destruction of epithelial tissues. These results highlight the potential utility of spirodiclofen, spiromesifen, and spirotetramat in integrated pest management for controlling P. gossypiella.
Keywords
Pectinophora gossypiella; Spirodiclofen; Spiromesifen; Spirotetramat; biological and histopathological studies; cuticle layers epithelial tissues
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