Multidrug Resistance of Escherichia coli From Poultry and Humans in contact: Serotyping, Resistance Genes, and Their Public Health Importance | ||||
| Egyptian Journal of Veterinary Sciences | ||||
| Articles in Press, Corrected Proof, Available Online from 18 August 2025 PDF (1.31 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejvs.2025.372867.2760 | ||||
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| Authors | ||||
Mohamed Elmorsy1; Hanan Ahmed Zaher2; Walaa Abu Elela3; Amani Marawan   4; Mostafa M. Eraqi5; Shimaa Ali Elbaz6
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| 1Department of Poultry and Rabbit Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt | ||||
| 2Department of Food Hygiene, Safety and Technology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt | ||||
| 3Fellow of Department of Poultry and Rabbit diseases, Faculty of Veterinary Medicine, Mansoura University, Egypt | ||||
| 4Microbiology department, faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt. Microbiology department, Faculty of Veterinary Medicine, Delta University for Science and Technology, Gamsa, Egypt. | ||||
| 5Microbiology and Immunology Department, Veterinary Research Institute, National Research Centre, Dokki, Giza 12622,Egypt | ||||
| 6Department of Hygiene and Zoonoses, Faculty of Veterinary Medicine, Mansoura university | ||||
| Abstract | ||||
| Chicken intestinal microbiome naturally includes Escherichia coli. However, only a small subset, known as avian pathogenic E. coli (APEC), may be harmful and zoonotic to humans. The study primary goal was to examine E. coli isolates from poultry and humans, serotype them, and find genes that confer resistance to popular antibiotics as well as drug sensitivity. The study tested 160 meat and organ samples from chickens and ducks, along with 40 human stool samples, finding E. coli in 15 % of samples, with the highest rates in human stool (40 %) and lower rates in duck (11.7 %), chicken organs (3.3%) and their meat (12.5 %). Thirty tested E. coli showed high resistance to several antibiotics, especially erythromycin, but were more sensitive to colistin and fosfomycin, with many strains showing resistance to multiple drugs. The isolates were analysed for some antibiotic resistance genes of E. coli. Duck and chicken organ isolates were found to be positive to aadA1, sul1, tetA, and msr-1 genes. Whereas their meat possessed aac(3)Iv, aadA1, sul1, tetA, msr-1 and aac(6)Ib genes. Human isolates carried ereA, aadA1, tetA, sul1, msr-1, and aac(3)Iv genes. In conclusion, the detection of shared antimicrobial resistance genes among E. coli isolates from both poultry and human sources strongly suggests a potential zoonotic transmission pathway. This highlights the substantial public health importance of these findings, indicating that avian E. coli contributes not only to economic losses in poultry production but also to the increasing burden of multidrug-resistant infections in both animal and human populations. | ||||
| Keywords | ||||
| E. coli; poultry; chicken and duck meat; human stool; multidrug resistance genes | ||||
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