Synthesis and Spectroscopic Investigation of Metal Complexes with a Novel Schiff-Azo Ligand: Antibacterial Screening and Anticancer Evaluation Against MCF-7 Cells | ||||
| Journal of Bioscience and Applied Research | ||||
| Articles in Press, Accepted Manuscript, Available Online from 18 August 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jbaar.2025.405254.1256 | ||||
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| Authors | ||||
Shaymaa Hamzah Daylee  1; Fawzi Yahya Wadday2
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| 1Department of Chemistry ,College of Education for Pure Science ,Karbala University ,Karbala -Iraq | ||||
| 2Department of Chemistry, Faculty of Science, Kufa University, Al-Najaf-Iraq, | ||||
| Abstract | ||||
| A novel ligand, 4-(((5-bromopyridin-2-yl)imino)methyl)-2-methoxy-6-((6-methoxybenzo[d]thiazol-2-yl)diazenyl)phenol (BIMTDP),, was created by the reaction of 2amino-6-methoxybenzothiazole with 4-hydroxy-3-methoxybenzaldehyde in anhydrous ethanol. This compound was then combined with 2amino-5-bromopyridine in the same solvent to create BIMTDP. A cluster of mononuclear complexes of this ligand was created with Co(II), Ni(II), Cu(II), Ag(I), Pt(IV), and Au(III) ions. The ligand and its metal complexes were recognized by means of mass spectrometry, 1H and 13C NMR spectroscopy, element analysis (C, H, N, S), XRD, FESEM, atomic absorption, UV-Vis and (FT-IR), as well as magnetic susceptibility and molar conductivity. The measured data regarding the composition of the metal complexes and the elemental analysis confirmed that the ratio of metal to ligand is of the type [M(L)], where M is Ag(I), Au(III) and [M(L)2], where M is Co(II), Ni(II), Cu(II), Pt(IV) and L is a azo-methylene ligand. Previous measurements from tetrahedral geometry for Ag(I) complexes, square planar for Au(III) complexes and other complex ions are discussed. All complexes had non-electrolytic properties, except for gold and platinum complexes, whose conductivities were both of 2:1 and 1:2, respectively. The compounds that were prepared also demonstrated a high degree of temporal stability and effective inhibitory activity towards two bacteria that are pathogenic, S. aureus and E. coli. The investigation also included the in vitro assessment of the toxicity of BIMTDP and its Au(III) complexes towards human breast cancer cells (MCF-7) | ||||
| Keywords | ||||
| : Mass spectroscopy; Complexation; Azomethine; Antimicrobial activity; Cancer cells | ||||
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