Relation of Epicardial Fat and Diabetic Nephropathy in Egyptian Patients | ||||
| Journal of Current Medical Research and Practice | ||||
| Volume 10, Issue 3, July 2025, Page 67-76 PDF (333.23 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jcmrp.2024.280648.1042 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohamed Abdel-Azeem Mohamed  ; Salwa Roshdy Dimitry; Magdy Ibrahim Aldesowky M. Algowhary
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| Department of Cardiology, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||||
| Abstract | ||||
| Abstract: Background: Visceral fat can be measured directly by epicardial fat thickness rather than anthropometric measurements. Two-dimensional (2D) echocardiography can accurately measure EFT. Our study pointed to detecting the role of EFT in predicting coronary artery disease (CAD), nephropathy, and affected vessels by 2D echocardiography. Methods: A cross-sectional, prospective study enrolled 120 patients who underwent coronary angiography and correlated the relation between EFT, nephropathy, and CAD. Patients signed informed consent. This study was approved by the ethical committee of the Faculty of Medicine, Assiut University (IRB Number: 17100450). Results: EFT was considered an independent risk factor for CAD (OR= 10.081, AUC= 0.936 with 86.5% accuracy at cut-off point > 0.55) and affected vessels (OR= 14.021, AUC= 0.981 with 87.5% accuracy at cut-off point > 0.45 cm) in diabetic patients. Also, we found that EFT was considered an independent risk factor for nephropathy (OR= 4.365, AUC= 0.601 with 72% accuracy at cut-off point > 0.45), CAD (OR= 18.635, AUC= 0.977 with 90.5% accuracy at cut-off point > 0.45) and affected vessels (OR= 8.826, AUC= 0.979 with 91.5% accuracy at cut-off point > 0.45 cm) in all studied patients. Conclusions: EFT assessment is a simple, non-invasive tool for predicting nephropathy and CAD and their severity. In addition to the known cardiovascular risk factors, EFT may help identify the risk of cardiovascular disease. Multi-center future studies are warranted to confirm such results. | ||||
| Keywords | ||||
| Keywords: Epicardial fat thickness; diabetic nephropathy; coronary artery disease | ||||
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