Viral Hepatitis B and C Infection in Patients with Idiopathic Thrombocytopenic Purpura Treated with Triple Therapy | ||||
| Journal of Current Medical Research and Practice | ||||
| Volume 10, Issue 3, July 2025, Page 105-112 PDF (417.72 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jcmrp.2024.284637.1049 | ||||
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| Authors | ||||
Mohammad A. Kobeisy; Safaa A. A. Khaled; Shymaa Mohamed Nageeb  ; Eman NasrEldin
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| Department of Internal Medicine, Assiut University Hospital, Faculty of Medicine, Assiut, Egypt. | ||||
| Abstract | ||||
| Abstract: Background: The immune thrombocytopenic purpura (ITP) disorder is linked to antiplatelet antibodies that destroy platelets. The most crucial factor in diagnosing it is a platelet count of less than 100 x 10^9/L. The purpose of this study was to determine the prevalence of viral HB and C infection in ITP patients treated with triple therapy versus those treated only with steroids. Additionally, the study aimed to examine the impact of viral HB and C infection on the clinical picture, treatment response, and side effects in ITP patients treated with steroids or triple therapy. Methods: This prospective longitudinal study was conducted on 100 patients with clinical and laboratory evidence of ITP eligible for triple or steroid therapy between December 2019 and June 2022. Patients were divided into two equal groups: Group A: ITP received triple therapy, and Group B: ITP received steroid therapy. Quantitative PCR was planned only for cases with positive serological markers. Results: After 6 months of therapy, patients treated with triple therapy had significantly higher platelets count than those who received steroids only. Also, random blood sugar was significantly lower in the steroid group. All groups had negative serology regarding HCV Abs and HBsAg during follow-up. Post-treatment platelet count had an insignificant correlation with all baseline variables. Conclusions: For patients with ITP, triple therapy is a safe, well-tolerated, and successful treatment. | ||||
| Keywords | ||||
| Keywords: Viral Hepatitis B; Viral Hepatitis C; Idiopathic Thrombocytopenic Purpura; Triple Therapy | ||||
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