A Comparative Study of Corneal Changes in Continuous and Pulsed Light Accelerated Corneal Cross-linking | ||||
| Journal of Current Medical Research and Practice | ||||
| Volume 10, Issue 3, July 2025, Page 189-200 PDF (327.55 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jcmrp.2025.369799.1240 | ||||
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| Authors | ||||
Duaa Ali  1; Mohammed Saad1; Ahmed Fathallah1; Mohammed Kamel2; Momen Aly2
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| 1Ophthalmology Department, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||||
| 2Ophthalmology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.. | ||||
| Abstract | ||||
| Abstract: Purpose: This study compared corneal changes (thickness, demarcation line depth on AS-OCT) and functional outcomes between pulsed and continuous accelerated corneal cross-linking (P-ACXL vs. C-ACXL) in patients with corneal in AS-OCT. Patients and Methods: This is a prospective interventional study; 33 eyes (18 patients) underwent epithelium-off P-ACXL or C-ACXL. Assessments included BCVA, refractive error (MRSE), keratometry (average K, KMAX), and AS-OCT-measured corneal parameters. Results: BCVA improved significantly in both groups at 1 and 3 months (p < 0.001), with no intergroup differences. Inferior corneal thickness was lower in C-ACXL vs. P-ACXL (478.94 ± 30.58 µm vs. 500.50 ± 38.17 µm; p=0.04). Corneal thickness decreased significantly from baseline in both groups (p<0.001). The demarcation line was shallower in C-ACXL at 1 and 3 months (p<0.001). Conclusions: Both P-ACXL and C-ACXL safely improved vision and reduced corneal thickness. The shallower demarcation line with C-ACXL may reflect distinct stromal remodeling patterns, warranting further study. | ||||
| Keywords | ||||
| Keywords: Keratoconus; corneal cross-linking; demarcation line (DL) in anterior segment OCT; pulsed light corneal cross-linking; ultraviolet A corneal cross-linking | ||||
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