Emergence of multidrug resistant opportunistic pathogens : A study on gram negative isolates from cancer patients | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 20 August 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2025.405064.3027 | ||||
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| Authors | ||||
lamiaa Fadel Alkilany  1; shaza Fadel Alkilany2; Azza Shibl3; Alaa Kadry Moawad4; Ayat Mohamed Sayed5; Shima Gafar Mansor6; Shaza fadel Alkilany2
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| 1Virology and Immunology Unit, Cancer Biology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt | ||||
| 2Public Health and Community Medicine Department, Faculty of Medicine, Minia University, Egypt | ||||
| 3Pediatric Oncology and Hematological Malignancies Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt | ||||
| 4Microbiology unit ,Clinical Pathology Department, South Faculty of medicine, Assiut University, Egypt | ||||
| 5Medical Oncology and Hematological Malignancy Department, South Egypt Cancer Institute, Assiut University, Egypt | ||||
| 6Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Egypt | ||||
| Abstract | ||||
| Background In developing countries, Cancer patients are considered the factory of multidrug-resistant organisms (MDROs). They are immunosuppressed because of both the disease status and chemotherapy regimens. This put the microorganisms under selective pressure that favors the development of multidrug resistant bacteria and even the emergence of new multidrug resistant strains. The problem of AMR is more evident in gram negative bacteria because it possesses a dynamic envelope that enables it to resist antibiotics. The aim of this study is to monitor antimicrobial resistance in a main cancer center at Upper Egypt to find gaps in the current knowledge improve the choices of empirical treatment and avoid potential future threats. Methods: This is a retrospective cross sectional study. This study depends on hospital medical records of Microbiology lab at South Egypt Cancer Institute (SECI) in 2- year period (2023-2024). Identification of microorganisms and antibiotic sensitivity tests were done by Vitek II automated system. Results : We found high frequency of infections by opportunistic microorganisms like Sphingomonas paucimobilis (6.2%) and Rauoltella spp (4.7%). Twenty five percent (25%) of Sphingomonas paucimobilis isolates were MDR and 25% of them were XDR .There was a significant increase in MDR and XDR isolates in 2024 compared to 2023 isolates. The most sensitive antibiotics in all specimens were aminoglycosides (resistance rate of amikin 40.6% and gentamicin 47.6%) followed by nitrofurantoin 51.6% resistance. Conclusion: Emergence of multidrug resistant strains of some opportunistic pathogens means urgent need for improving infection control measures and avoiding antibiotic misuse. | ||||
| Keywords | ||||
| Antibiotic; resistance; cancer; sphingomanas paucimobilis; opportunistic | ||||
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