Vitamin B5 (Pantothenic Acid) as a New Insight and Treatment of Oligohydramnios | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 169, Volume 100, Issue 1, July 2025, Page 3724-3728 PDF (599.74 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2025.448747 | ||||
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| Abstract | ||||
| Background: Oligohydramnios has low amniotic fluid volume, and causes neonatal comorbidity. Vitamin B5, is a water-soluble vitamin involved in metabolism. Aquaporin 1 (AQP1) is a water channel protein. Protein kinase B (AKT) is a signalling molecule involved in multiple cellular processes. Objectives: To assess the clinical efficacy of vitamin B5 in the treatment of idiopathic oligohydramnios and its related adverse fetal/neonatal outcomes, and investigating the role of AQP1 and AKT1 in idiopathic oligohydramnios pathogenesis. Patients and methods: Vitamin B5 was given to group 1 (n=80), while group 2 (n=63) received placebo as a control group. Patients of both groups have idiopathic oligohydramnios. The amniotic fluid index (AFI), mode of delivery, and perinatal outcome were documented. The gene expression levels of AQP1 and AKT1 were assayed in subgroups (G1a), and (G2a) of 8 idiopathic oligohydramnios patients each, where G1a got vitamin B5, and G2a got placebo. In addition to group 3 of 8 normal pregnant females. Results: In group 1, AFI was increased in 76.2 %, steady in 22.6 %, and decreased in 1.2 % of patients; while in group 2, AFI was steady in 6.4 %, and decreased in 93.6 % of patients. Group 2 showed significant decline in normal vaginal delivery, and rise in lower segment caesarean section (LSCS) in comparison with group 1. The current study showed significant changes in gene expression levels of AQP1, and AKT1 among studied groups. Conclusion: Vitamin B5 acted as effective treatment in idiopathic oligohydramnios. AQP1 and AKT1 may contribute in idiopathic oligohydramnios pathogenesis. | ||||
| Keywords | ||||
| Amniotic fluid index; Oligohydramnios; Maximum vertical pocket; Pantothenic acid | ||||
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