Tripolyphosphate-Driven Synthesis of Ag3PO4-Decorated Chitosan Nanoparticles for Enhanced Antimicrobial Activity | ||
| Egyptian Journal of Chemistry | ||
| Volume 69, Issue 2, February 2026, Pages 477-487 PDF (1.4 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2025.400788.11998 | ||
| Authors | ||
| Asmaa N. Alafifya1; Ghada Dawwam2; Soheir Abdel Salam1; Manal Selim Mohamed3; Mona Tawfik Al-Shemy* 4 | ||
| 1Botany and Microbiology Department, Faculty of Science, Benha University, Benha, 13518, Egypt. | ||
| 2Botany and Microbiology Department, Faculty of Science, Benha University, Benha, 13518, Egypt | ||
| 3Microbial Biotechnology Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt | ||
| 4National research centre Cellulose & Paper Department | ||
| Abstract | ||
| Overuse of conventional antibiotics has fueled the rise of drug-resistant pathogens, creating an urgent need for novel antimicrobial platforms. In this study, we developed a novel, green, one-pot tripolyphosphate-driven method to fabricate chitosan (CS) nanoparticles from black soldier fly (Hermetia illucens) puparia and simultaneously deposit crystalline Ag3PO4 (AgP) domains to yield a CS@AgP bionanocomposite. Comprehensive FTIR, XRD, and UV–Vis DRS analyses confirmed successful Ag3PO4 incorporation and a narrowed direct band gap of 1.46 eV. Agar-diffusion assays against Gram-positive (L. monocytogenes ATCC 7646, S. aureus ATCC 6538), Gram-negative (E. coli ATCC 25922, Salmonella sp. ATCC 14028), and fungal (C. albicans ATCC 10231) strains demonstrated dose-dependent inhibition zones up to 30 mm at 25 mg/mL. This dual-function nanocomposite combines sustainable, single-step production with broad visible-light absorption and potent antimicrobial efficacy, offering a versatile platform for antimicrobial coatings and photocatalysis. | ||
| Keywords | ||
| Bio-nanocomposite; Chitosan nanoparticles (CSNPs); Green synthesis; Pathogenic microbes; Soldier fly Puparia; Silver phosphate (Ag₃PO₄) nanoparticles | ||
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