Evaluation of Hypoglycemic and Hypolipidemic potentials of Aqueous Extracts of Guava and Mango leaves in Streptozotocin Diabetic Rats | ||||
| مجلة الاقتصاد المنزلي | ||||
| Volume 41, Issue 4, December 2025, Page 1-24 PDF (393.58 K) | ||||
| Document Type: المقالة الأصلية | ||||
| DOI: 10.21608/jhe.2025.449248 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Eman S. Mohamed1; Sonia S. El-Maraasy1; Eman S. Ibrahim2; Hany G. El-Masry1 | ||||
| 1Nutrition and Food Science Department, Faculty of Home Economics, Helwan University | ||||
| 2Regional Center for Food and Feed, Agriculture Research Center, Giza, Egypt | ||||
| Abstract | ||||
| The purpose of this study was to evaluate the hypoglycemic and hypolipidemic effects of aqueous extracts of Guava and Mango leaves either used separately or in a mixture in streptozotocin -induced diabetic rats. Thirty male adult rats were divided into five groups, each with six rats, and evaluated as follows: group 1 normal non diabetic rats (negative control); group 2 Diabetic untreated rats (positive control); group 3 diabetic treated with Guava leaves aqueous extract (GLAE) (500 mg/kg b.wt/day); group 4 :diabetic treated with Mango leaves aqueous extract (MLAE)(500 mg/kg b.wt/day); group five: diabetic treated with mixture of both tested plants extract. After four weeks of extracts administration, blood samples were taken to assess several biochemical markers. The results of the present study demonstrated a significant elevation in blood glucose levels, accompanied by a marked reduction in serum insulin concentrations in diabetic untreated rats, compared to normal (negative control) rats. Furthermore, the diabetic untreated group (positive control) exhibited a significant increase in serum levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and very-low-density lipoprotein cholesterol (VLDL-C), along with a significant decrease in high-density lipoprotein cholesterol (HDL-C), compared to the negative control group. Streptozotocin administration also induced a noticeable loss in body weight gain in the diabetic untreated rats. In contrast, oral administration of aqueous extracts of guava and mango leaves, either individually or in combination, in diabetic rats resulted in significant reductions in blood glucose levels and significantly improved serum insulin concentrations. Moreover, notable improvements in the lipid profile were observed, as evidenced by a significant reduction in serum total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDL-C), along with a significant increase in high-density lipoprotein cholesterol (HDL-C), compared to diabetic untreated rats (positive control). Additionally, the weight loss induced by streptozotocin was ameliorated by treatment with guava leaf extract, mango leaf extract, or their combination. Both plant extracts demonstrated significant hypoglycemic and hypolipidemic effects in diabetic rats. These results highlight the therapeutic potential of aqueous extracts of guava and mango leaves either used separately or in a mixture for the management of type 2 diabetes accompanied by hyperlipidemia. | ||||
| Keywords | ||||
| Guava leaves; Mango leaves; Diabetes mellitus; Streptozotocin; glucose levels; insulin levels and rats | ||||
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