Comparison between trichloroacetic acid solution 50% and hydrogen peroxide solution 40% in cases diagnosed clinically and dermoscopically as seborrheic keratosis
Almohammady, A., Maawad, A., Mansour, A., Dorgham, H. (2025). Comparison between trichloroacetic acid solution 50% and hydrogen peroxide solution 40% in cases diagnosed clinically and dermoscopically as seborrheic keratosis. EKB Journal Management System, 2025(3), 168-173. doi: https://doi.org/10.21608/aimj.2025.446482
Abd-Elshakour Abd-Elhafiz Almohammady; Ahmed Nabil Maawad; Ahmed Mohamed Mansour; Hatem Ibrahim Dorgham. "Comparison between trichloroacetic acid solution 50% and hydrogen peroxide solution 40% in cases diagnosed clinically and dermoscopically as seborrheic keratosis". EKB Journal Management System, 2025, 3, 2025, 168-173. doi: https://doi.org/10.21608/aimj.2025.446482
Almohammady, A., Maawad, A., Mansour, A., Dorgham, H. (2025). 'Comparison between trichloroacetic acid solution 50% and hydrogen peroxide solution 40% in cases diagnosed clinically and dermoscopically as seborrheic keratosis', EKB Journal Management System, 2025(3), pp. 168-173. doi: https://doi.org/10.21608/aimj.2025.446482
Almohammady, A., Maawad, A., Mansour, A., Dorgham, H. Comparison between trichloroacetic acid solution 50% and hydrogen peroxide solution 40% in cases diagnosed clinically and dermoscopically as seborrheic keratosis. EKB Journal Management System, 2025; 2025(3): 168-173. doi: https://doi.org/10.21608/aimj.2025.446482

Comparison between trichloroacetic acid solution 50% and hydrogen peroxide solution 40% in cases diagnosed clinically and dermoscopically as seborrheic keratosis

Al-Azhar International Medical Journal
Volume 2025, Issue 3, March 2025, Page 168-173  XML PDF (566.2 K)
Document Type: Original Article
DOI: https://doi.org/10.21608/aimj.2025.446482
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Authors
Abd-Elshakour Abd-Elhafiz Almohammady1; Ahmed Nabil Maawad2; Ahmed Mohamed Mansour3; Hatem Ibrahim Dorgham* 4
1Professor of Dermatology, Venereology and Andrology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
2Lecturer of Dermatology, Venereology and Andrology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
3Professor of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
4MBBCh., Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Abstract
Background: Epidermal tumors, such as seborrheic keratosis (SK), are common in middle-aged and older people. SK develops when immature keratinocytes benignly proliferate, leaving behind flat, round, or oval macules that are easily distinguished. They don't usually develop quickly, can get thicker with time, and almost never go away on their own.
Aim and objectives: To compare the efficacy and safety of hydrogen peroxide (H2O2) 40% solution versus trichloroacetic acid (TCA) 50% solution in the treatment of seborrheic keratosis.
Patients and methods: This randomized control trial carried out on 100 patients diagnosed clinically and dermoscopically as SK attending at El-Hussein hospital, Al-Azhar University, Cairo from April 2023 to November 2024. Patients were divided into two equal groups: Group A: received topical hydrogen peroxide 40% solution was used every 3 weeks for 3 months and Group B: received topical TCA 50% solution was used every 3 weeks for 3 months.
Results: While differences in improvement according to location were statistically significant, differences according to gender, age, and smoking status were not.
Conclusion: Our study revealed that, although H2O2 solution 40% provides significant improvement in treatment of SK, topical TCA 50% solution is more effective. In two groups the site affects the precent of improvement.
 
Keywords
Seborrheic keratosis; Hydrogen peroxide (H2O2); Trichloroacetic acid (TCA)
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