Regulatory T cells in Active Systemic Lupus Erythematosus patients
Abd-Allatif, S., Mosa, M., Moustafa, S., El-Shazly, Y. (2025). Regulatory T cells in Active Systemic Lupus Erythematosus patients. EKB Journal Management System, 2025(3), 191-194. doi: https://doi.org/10.21608/aimj.2025.446486
Salama Saad Abd-Allatif; Mohamed Farouk Ibrahim Mosa; Sami Abd-Elhakeem Moustafa; Youssef Nasser Youssef El-Shazly. "Regulatory T cells in Active Systemic Lupus Erythematosus patients". EKB Journal Management System, 2025, 3, 2025, 191-194. doi: https://doi.org/10.21608/aimj.2025.446486
Abd-Allatif, S., Mosa, M., Moustafa, S., El-Shazly, Y. (2025). 'Regulatory T cells in Active Systemic Lupus Erythematosus patients', EKB Journal Management System, 2025(3), pp. 191-194. doi: https://doi.org/10.21608/aimj.2025.446486
Abd-Allatif, S., Mosa, M., Moustafa, S., El-Shazly, Y. Regulatory T cells in Active Systemic Lupus Erythematosus patients. EKB Journal Management System, 2025; 2025(3): 191-194. doi: https://doi.org/10.21608/aimj.2025.446486

Regulatory T cells in Active Systemic Lupus Erythematosus patients

Al-Azhar International Medical Journal
Volume 2025, Issue 3, March 2025, Page 191-194  XML PDF (267.72 K)
Document Type: Original Article
DOI: https://doi.org/10.21608/aimj.2025.446486
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Authors
Salama Saad Abd-Allatif1; Mohamed Farouk Ibrahim Mosa1; Sami Abd-Elhakeem Moustafa2; Youssef Nasser Youssef El-Shazly* 1
1Department of Clinical Pathology, Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt.
2Department of Rheumatology & Rehabilitation, Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt.
Abstract
 
Background: A complex autoimmune disease, systemic lupus erythematosus (SLE) manifests itself throughout the course of a long, relapsing-remitting illness with a broad spectrum of symptoms that can range from mild discomfort to complete disability. When it comes to autoimmune disorders like SLE, there's some indication that changes in Treg numbers or function could have a role in the development of the disease.
The Aim of the work: evaluation of the proportions of CD 4+CD 25+CD 127- T regulatory cells in SLE patients in relation to disease activity.
Patients and methods: One hundred patients with systemic lupus erythematosus were studied, with each patient divided into two groups based on disease activity as measured by the Systemic Lupus Erythematosus Disease Activity Index. Thirty healthy persons served as a control group.
Results: When comparing the percentage value of (CD 4+CD 25+CD127-cells) between the active and control groups, as well as between the examined groups (inactive SLE and active SLE), there was a highly significant difference (P<0.001). Conversely, when looking at the absolute value of (CD4+CD25+CD127-cells), there was no statistically significant distinction (P=0.484) between the control group and the inactive SLE group.
Conclusion: Tregs may be utilized as an activity biomarker due to the strong correlation between the percentage of Treg cells and SLE activity. More large-scale research is needed to determine the function of Tregs in SLE and to establish a connection between Tregs and disease parameters that impact mortality and morbidity.
 
Keywords
SLE; T Regulatory cells(Tregs); (SELDAI)
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