Study of the Role of Erythrocyte Glutathione Transferase as A potential Marker of Haemodialysis Adequacy | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2025, Issue 3, March 2025, Page 247-252 PDF (351.05 K) | ||||
| Document Type: Original Article | ||||
| DOI: https://doi.org/10.21608/aimj.2025.446496 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Nagwa Mohammed Mowafy1; Muhammad Abd Alhameed Basyony Khedr2; Farag khalil Farag Ebrahim3; Mohamed Abed Al Kareem Soliman Aleysawy* 4 | ||||
| 1Professor of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| 2Assistant Professor of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| 3Professor of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| 4MBBCh, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. | ||||
| Abstract | ||||
| Abstract Background: The high prevalence of complications and fatalities caused by end-stage renal disease (ESRD) makes it a major issue in global public health. Over the past three decades, the prevalence of chronic kidney disease (CKD) has increased dramatically on a global scale. Aim and objectives: Our goal is to find out whether erythrocyte glutathione transferase (E-GST) is just another urea measurement that goes along with Kt/V hemodialysis (HD) or if it's a new way to tell if dialysis is working well. Patients and methods: In this cross-sectional study, which lasted from August 2023 to August 2024 and was structured according to hemodialysis mode, forty patients with end-stage renal disease (ESRD) who were regularly treated at the hemodialysis units of Al-Hussein and Said Galal Al-Azhar university hospitals were included. Patients were divided into two equal groups according to gender and age. Results: When it comes to measuring hemodialysis adequacy, E-GST is just as effective as URR and Kt/V Urea. It serves as an additional indicator that reflects URR and Kt/V values, and there is no statistically significant distinction between traditional HD and post-dilutional online hemofiltration (OL-HDF) (P-value>0.05). Conclusion: Hemodialysis adequacy and the elimination of toxins in multiple sessions by different hemodialysis modalities can be expressed by the amount of E-GST, a hemodialysis patient marker that is both sensitive and specific. | ||||
| Keywords | ||||
| E-GST; Haemodialysis adequacy | ||||
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