Relationship between Vitamin D Deficiency and Menopause-Associated Symptoms in Postmenopausal Women | ||
| Zagazig University Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 26 August 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2025.396165.4011 | ||
| Authors | ||
| Basem Mohammed Hamed1; Ali El-Shabrawy Ali2; Ahmed Gamal El-Sayed Mohammed* 3; Ahmed Metwally El-Kattawy4 | ||
| 1Assistant Professor of Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig university, Egypt | ||
| 2Professor of Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig university, Egypt | ||
| 3Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt | ||
| 4Lecturer of Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig university, Egypt | ||
| Abstract | ||
| Background: Menopause is a natural transition marked by decreasing estrogen levels. Vitamin D deficiency is common in postmenopausal women, and it is necessary for calcium absorption and bone health. Although the specific relationship between low vitamin D levels and the severity of menopausal symptoms is uncertain, current study suggests a probable link. The present study aims to explore if there is any association between vitamin D status and the severity of menopause-related symptoms. Methods: This Cross-sectional study was conducted in the Obstetrics and Gynecology Department, Zagazig University Hospitals, involving 305 postmenopausal women. Women were divided into two groups based on vitamin D levels: Group I: 98women with sufficient vitamin D (>30ng/ml), aged 52-64years. Group II: 207women with insufficient vitamin D (<30ng/ml), aged 52-64years. Participants underwent detailed history taking, clinical examination, and serum vitamin D measurement using the 25-OH vitamin D kit. Results: Vitamin D insufficiency was observed in 52.4% of the studied population. The study demonstrated a positive correlation between vitamin D levels and both age and menopausal duration, while a negative correlation was found with BMI and MRS scores. Multiple regression analysis identified vitamin D as an independent negative predictor of MRS. ROC analysis determined that a vitamin D cutoff of 26.3 ng/mL yielded the highest sensitivity (88.24%) and specificity (61.18%) for detecting severe MRS scores, with an area under the curve of 0.798. Conclusion: Vitamin D deficiency is a concerning problem among postmenopausal women; however, it does not appear to be linked to the severity of menopausal symptoms. | ||
| Keywords | ||
| Menopause; Vitamin D insufficiency; Postmenopausal Women | ||
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